Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro

被引：28

作者：

Fan, Ling-Ling ^{[1
]}

Huang, Ning ^{[2
,3
]}

Yang, Rui-Ge ^{[1
]}

He, Shu-Zhen ^{[1
]}

Yang, Liu-Meng ^{[2
]}

Xu, Hui ^{[1
]}

Zheng, Yong-Tang ^{[2
]}

机构：

[1] NW A&F Univ, Coll Sci, Lab Pharmaceut Design & Synth, Yangling 712100, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Chinese Acad Sci & Yunnan Prov, Kunming 650223, Yunnan, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2012年 / 9卷 / 01期

关键词：

5,6-Dihydro-indolo[1,2-a]quinoxaline; Acquired immunodeficiency syndrome; Human immunodeficiency virus-1; Inhibitor; AGENTS; ANALOGS;

D O I：

10.2174/157018012798193026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In continuation of our program to find compounds with potent anti-human immunodeficiency virus type 1 (HIV-1) activities, seventeen 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives (1-17) were preliminarily evaluated as HIV-1 inhibitors in vitro. Among all the derivatives, especially compounds 10 and 17 showed the most potent anti-HIV-1 activities with EC50 values of 2.42 and 3.39 mu g/mL, and TI values of 63.76 and 53.60, respectively.

引用

页码：44 / 47

页数：4

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