QuantiFERON®-TB Gold in the diagnosis of active tuberculosis

被引：23

作者：

Bartu, V. ^{[1
]}

Havelkova, M. ^{[2
]}

Kopecka, E. ^{[1
]}

机构：

[1] Charles Univ Prague, Dept Resp Dis, Sch Med 1, Thomayer Fac Hosp, Prague 14000 4, Czech Republic

[2] Natl Inst Hlth, Prague, Czech Republic

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2008年 / 36卷 / 03期

关键词：

active tuberculosis; diagnostic method; QuantiFERON (R)-TB gold; tuberculin skin test;

D O I：

10.1177/147323000803600307

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

QuantiFERON (R)-TB Gold (QFT) is an indirect diagnostic test for latent tuberculosis (TB) infection and active TB. This study aimed to evaluate and compare QFT and the tuberculin skin test (TST) for the diagnosis of active TB disease, not bacteriologically verified at the time of therapy initiation. Seventy-three patients with suspected active TB were examined. Further diagnostic steps confirmed the diagnosis Of active TB in 53 persons. QFT was positive in 43 persons (81%), negative in seven (13%), and indeterminate results were found in three (6%). The sensitivity of the test was 86% in those with valid results, significantly higher than that for the TST (62%), and the correlation between the two tests was not high (55%). The QFT test is a useful addition to existing methods for the diagnosis of active TB.

引用

页码：434 / 437

页数：4

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