Iron-catalyzed aerobic oxidative phosphonation of N-aryl tetrahydroisoquinolines

被引：7

作者：

Cai, Junjie ^{[1
]}

Liu, Yingle ^{[1
]}

Jiang, Yan ^{[1
]}

Yang, Yi ^{[1
]}

机构：

[1] Sichuan Univ Sci & Engn, Coll Chem & Environm Engn, Key Lab Green Catalysis Higher Educ Inst Sichuan, 180 Xueyuan St,Huixing Rd, Zigong 643000, Sichuan, Peoples R China

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2017年 / 192卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Oxidative phosphonation; iron catalysis; coupling; alpha-aminophosphonate; DEHYDROGENATIVE-COUPLING REACTIONS; C-H FUNCTIONALIZATION; BOND-FORMING REACTIONS; TERTIARY-AMINES; ALPHA-AMINOPHOSPHONATES; BIOLOGICAL-PROPERTIES; ANTITUMOR-ACTIVITY; ACID-DERIVATIVES; EFFICIENT; INHIBITORS;

D O I：

10.1080/10426507.2017.1330827

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We report herein a novel and efficient method for iron-catalyzed aerobic oxidative phosphonation of N-aryl tetrahydroisoquinolines for the synthesis of biologically interesting alpha-aminophosphonates. This new C-P bond formation reaction features the employment of a sustainable and cost-effective iron salt [Fe(NO3)(3)center dot 9H(2)O] as catalyst, the utilization of air as environmental-benign oxidant, as well as the user-friendly open-flask reaction conditions.

引用

页码：1068 / 1073

页数：6

共 72 条

[1] Molybdenum trioxide catalyzed oxidative cross-dehydrogenative coupling of benzylic sp3 C-H bonds: synthesis of α-aminophosphonates under aerobic conditions [J].