Adaptive activation of thyroid hormone and energy expenditure

被引：111
作者：
Bianco, AC [1 ]
Maia, AL [1 ]
da Silva, WS [1 ]
Christoffolete, MA [1 ]
机构：
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp,Dept Med, Div Endocrinol Diabet & Hypertens,Thyroid Sect, Boston, MA 02115 USA
来源：
BIOSCIENCE REPORTS | 2005年 / 25卷 / 3-4期
关键词：
deiodinase; brown adipose tissue; skeletal muscle; uncoupling protein;
D O I：
10.1007/s10540-005-2885-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanisms by which thyroid hormone accelerates energy expenditure are poorly understood. In the brown adipose tissue (BAT), activation of thyroid hormone by type 2 iodothyronine deiodinase (D2) has been known to play a role in adaptive energy expenditure during cold exposure in human newborns and other small mammals. Although BAT is not present in significant amounts in normal adult humans, recent studies have found substantial amounts of D2 in skeletal muscle, a metabolically relevant tissue in humans. This article reviews current biological knowledge about D2 and adaptive T3 production and their roles in energy expenditure.
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页码：191 / 208
页数：18
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