Biological Activities of Synthetic Oligosaccharides and Glycolipids from Mycobacteria

被引：17
作者：
Hutacharoen, Panatpong [1 ,2 ,3 ]
Ruchirawat, Somsak [2 ,3 ,4 ]
Boonyarattanakalin, Siwarutt [1 ]
机构：
[1] Thammasat Univ, Sirindhorn Int Inst Technol, Sch Biochem Engn & Technol, Pathum Thani 12121, Thailand
[2] Chulabhorn Grad Inst, Program Chem Biol, Bangkok 10210, Thailand
[3] Ctr Excellence Environm Hlth Toxicol & Management, Bangkok 10210, Thailand
[4] Chulabhorn Res Inst, Med Chem Lab, Bangkok 10210, Thailand
来源：
JOURNAL OF CARBOHYDRATE CHEMISTRY | 2011年 / 30卷 / 7-9期
关键词：
Mycobacteria; Mycobacterium tuberculosis (Mtb); Glycolipid; Lipoglycan; Synthetic oligosaccharide; PHOSPHATIDYLINOSITOL MANNOSIDES; DC-SIGN; CORD FACTOR; TREHALOSE DIMYCOLATE; CELL-WALL; PROINFLAMMATORY CYTOKINES; LIPOMANNAN COMPONENT; AUTOMATED SYNTHESIS; ADJUVANT ACTIVITIES; CHEMICAL-SYNTHESIS;
D O I：
10.1080/07328303.2011.621041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glycolipids are essential components of mycobacterial cell envelopes. They are highly bioactive and involved in many aspects of virulence and persistence of mycobacteria. Many glycolipids have been isolated from mycobacterial surfaces. Some mycobacterial glycans and glycolipids, as well as their analogs, have been chemically synthesized. This report focuses on recent contributions in the synthesis of mycobacterial glycans and glycolipids to the study of their biological mechanisms and to the optimization of their activities, with highlights on the lipid and saccharide mimetics.
引用
收藏
页码：415 / 437
页数：23
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