Blood cell apoptosis/necrosis - Some clinical and laboratory aspects

被引：8
作者：
Seghatchian, J
De Sousa, G
机构：
[1] Blood Component Technol Consultancy, London, England
[2] Lisbon Reg Blood Ctr, Lisbon, Portugal
来源：
APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷
关键词：
TGF beta; transfusion complications; apoptosis; microvesiculation; DNA fragmentation;
D O I：
10.1196/annals.1299.100
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Exposure of phosphatidyl-serine on blood cell membrane surface and microvesiculation as the hallmarks of apoptosis/necrosis were investigated. The effect of leukofiltration on the retention/generation of microvesicules, leukocyte subsets and major biological response modifiers were evaluated in a like study. It is concluded that apoptotic cells potentially contribute to transfusion reactions in donor/recipient-specific ways.
引用
收藏
页码：540 / 547
页数：8
相关论文
共 5 条
[1]   Apoptosis, transforming growth factor-β, and the immunosuppressive effect of transfusion [J].
Dzik, S ;
Mincheff, M ;
Puppo, F .
TRANSFUSION, 2002, 42 (09) :1221-1223
[2]   Are all leucodepleted platelet concentrates equivalent? Comparison of Cobe LRS Turbo, haemonetics MCS plus LD, and filtered pooled buffy-coat-derived platelets [J].
Krailadsiri, P ;
Seghatchian, J .
VOX SANGUINIS, 2000, 78 (03) :171-175
[3]   Residual red cell and platelet content in WBC-reduced plasma measured by a novel flow cytometric method [J].
Krailadsiri, P ;
Seghatchian, J .
TRANSFUSION AND APHERESIS SCIENCE, 2001, 24 (03) :279-286
[4]   Studies on the characterisation of the cause of leucoreduction failures, with particular reference to extra gatal events [J].
Seghatchian, J ;
Krailadsiri, P ;
Beard, M ;
Bukasa, A ;
Bashir, S .
TRANSFUSION AND APHERESIS SCIENCE, 2002, 26 (01) :47-60
[5]  
TRINDADE H, TRANSFUSION APHERESI, V28, P319
1