Diazaspiro-iminosugars and polyhydroxylated spiro-bislactams: synthesis, glycosidase inhibition and molecular docking studies

被引：12

作者：

Parihar, Vijay Singh ^{[1
,2
]}

Pawar, Nitin J. ^{[1
,2
]}

Ghosh, Sougata ^{[3
]}

Chopade, Balu ^{[3
]}

Kumbhar, Navanath ^{[1
,2
]}

Dhavale, Dilip D. ^{[1
,2
]}

机构：

[1] Savitribai Phule Pune Univ, Garware Res Ctr, Dept Chem, Pune 411007, Maharashtra, India

[2] Univ Pune, Pune 411007, Maharashtra, India

[3] Savitribai Phule Pune Univ, Dept Microbiol, Pune 411007, Maharashtra, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 65期

关键词：

PIPERIDINE; AZASPIROCYCLES; DERIVATIVES; MECHANISM; DESIGN; POTENT;

D O I：

10.1039/c5ra09584k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of a new class of iminosugars 1-4 has been reported. The Jocic-Reeve and Corey-Link approach with alpha-D-glucofuranos-3-ulose 5 afforded 3-azidoaldehyde 7 that was converted to the gamma-lactam 9. Reductive aminocyclisation and Schmidt-Boyer reactions were used to get spiro-iminosugars 1-4 which showed selective and potent glycosidase inhibitory activities. Molecular docking studies support the activity data.

引用

页码：52907 / 52915

页数：9

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