Immunomodulatory significance of natural peptides in mammalians: Promising agents for medical application

被引：31
作者：
Cai, Jinyang [2 ]
Li, Xin [3 ]
Du, Hongming [4 ]
Jiang, Chengfei [5 ]
Xu, Siliang [6 ]
Cao, Yan [1 ]
机构：
[1] Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, Womens Hosp, Nanjing Matern & Child Hlth Care Inst, Nanjing 210004, Jiangsu, Peoples R China
[2] Nanjing Med Univ, State Key Lab Reprod Med, Nanjing 211166, Jiangsu, Peoples R China
[3] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China
[4] Nanjing Med Univ, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, Nanjing 210029, Jiangsu, Peoples R China
[5] Nanjing Med Univ, Dept Pathol, Nanjing 211166, Jiangsu, Peoples R China
[6] Nanjing Med Univ, Affiliated Hosp 1, Clin Ctr Reprod Med, State Key Lab Reprod Med, Nanjing 210029, Jiangsu, Peoples R China
来源：
IMMUNOBIOLOGY | 2020年 / 225卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Immunomodulatory effects; Host defence peptides; Milk-derived peptides; Mammalians; Drug development; HOST-DEFENSE PEPTIDES; HUMAN CATHELICIDIN LL-37; ANTIMICROBIAL PEPTIDE; BOVINE GLYCOMACROPEPTIDE; BIOACTIVE PEPTIDES; INNATE IMMUNITY; BETA-CASEIN; VITAMIN-D; MILK; INFLAMMATION;
D O I：
10.1016/j.imbio.2020.151936
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Modulation of immune responses by immunoregulatory agents, such as the natural or synthetic immunomodulatory peptides, has been suggested as a potential strategy to modulate immune system against infection and other immune-related diseases. These compositionally simple peptides have attracted much attention for many drug developers, due to their high activity, low toxicity and clear target specificity. Host defence peptides and milk-derived peptides are two kinds of natural immunomodulatory peptides which have been widely studied in mammalians. They could participate at the interface of innate and adaptive immunity by regulating immune effector cells. This review summarizes the recent advances in host defence peptides and milk-derived peptides as well as their general characteristics, immunomodulatory functions and possible applications.
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页数：9
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