Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis

被引：99
作者：
Clocchiatti, Andrea
Florean, Cristina
Brancolini, Claudio [1 ]
机构：
[1] Univ Udine, Dipartimento Sci Med & Biol, I-33100 Udine, Italy
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2011年 / 15卷 / 09期
关键词：
chromatin; differentiation; apoptosis; MEF2; epigenetic; HDAC4; HDAC5; HDAC7; HDAC9; cancer; RUNX2; PROTEIN-KINASE-D; HISTONE DEACETYLASE 4; CONTROLS CHONDROCYTE HYPERTROPHY; MYOCYTE ENHANCER FACTOR-2; MEF2 TRANSCRIPTION FACTOR; NUCLEAR EXPORT; GENE-EXPRESSION; SKELETAL-MUSCLE; CANCER-CELLS; DEPENDENT REGULATION;
D O I：
10.1111/j.1582-4934.2011.01321.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Histone deacetylases (HDACs) are important regulators of gene expression. Specific structural features and distinct regulative mechanisms rationalize the separation of the 18 different human HDACs into four classes. The class II comprises a heterogeneous group of nuclear and cytosolic HDACs involved in the regulation of several cellular functions, not just limited to transcriptional repression. In particular, HDAC4, 5, 7 and 9 belong to the subclass IIa and share many transcriptional partners, including members of the MEF2 family. Genetic studies in mice have disclosed the fundamental contribution of class IIa HDACs to specific developmental/differentiation pathways. In this review, we discuss about the recent literature, which hints a role of class IIa HDACs in the development, growth and aggressiveness of cancer cells.
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页码：1833 / 1846
页数：14
相关论文
共 145 条
[1]   A redox-dependent pathway for regulating class IIHDACs and cardiac hypertrophy [J].
Ago, Tetsuro ;
Liu, Tong ;
Zhai, Peiyong ;
Chen, Wei ;
Li, Hong ;
Molkentin, Jeffery D. ;
Vatner, Stephen F. ;
Sadoshima, Junichi .
CELL, 2008, 133 (06) :978-993
[2]   MEF2C transcription factor controls chondrocyte hypertrophy and bone development [J].
Arnold, Michael A. ;
Kim, Yuri ;
Czubryt, Michael P. ;
Phan, Dillon ;
McAnally, John ;
Qi, Xiaoxia ;
Shelton, John M. ;
Richardson, James A. ;
Bassel-Duby, Rhonda ;
Olson, Eric N. .
DEVELOPMENTAL CELL, 2007, 12 (03) :377-389
[3]   Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4 [J].
Backs, Johannes ;
Backs, Thea ;
Bezprozvannaya, Svetlana ;
McKinsey, Timothy A. ;
Olson, Eric N. .
MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (10) :3437-3445
[4]   DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines [J].
Basile, V ;
Mantovani, R ;
Imbriano, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (04) :2347-2357
[5]   SIK1 is a class IIHDAC kinase that promotes survival of skeletal myocytes [J].
Berdeaux, Rebecca ;
Goebel, Naomi ;
Banaszynski, Laura ;
Takemori, Hiroshi ;
Wandless, Thomas ;
Shelton, G. Diane ;
Montminy, Marc .
NATURE MEDICINE, 2007, 13 (05) :597-603
[6]   A large-scale RNAi screen in human cells identifies new components of the p53 pathway [J].
Berns, K ;
Hijmans, EM ;
Mullenders, J ;
Brummelkamp, TR ;
Velds, A ;
Heimerikx, M ;
Kerkhoven, RM ;
Madiredjo, M ;
Nijkamp, W ;
Weigelt, B ;
Agami, R ;
Ge, W ;
Cavet, G ;
Linsley, PS ;
Beijersbergen, RL ;
Bernards, R .
NATURE, 2004, 428 (6981) :431-437
[7]  
BODILY JM, 2010, CANCER RES, V73, P1187
[8]   Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death [J].
Bolger, TA ;
Yao, TP .
JOURNAL OF NEUROSCIENCE, 2005, 25 (41) :9544-9553
[9]  
Borghi S, 2001, J CELL SCI, V114, P4477
[10]   Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain [J].
Bottomley, Matthew J. ;
Lo Surdo, Paola ;
Di Giovine, Paolo ;
Cirillo, Agostino ;
Scarpelli, Rita ;
Ferrigno, Federica ;
Jones, Philip ;
Neddermann, Petra ;
De Francesco, Raffaele ;
Steinkuhler, Christian ;
Gallinari, Paola ;
Carfi, Andrea .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (39) :26694-26704
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