Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults - a report on 90 patients

被引：45

作者：

Damodar, S ^{[1
]}

Viswabandya, A ^{[1
]}

George, B ^{[1
]}

Mathews, V ^{[1
]}

Chandy, M ^{[1
]}

Srivastava, A ^{[1
]}

机构：

[1] Christian Med Coll & Hosp, Dept Haematol, Vellore 632004, Tamil Nadu, India

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2005年 / 75卷 / 04期

关键词：

dapsone; idiopathic thrombocytopenic purpura;

D O I：

10.1111/j.1600-0609.2005.00545.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Data on 90 patients (55 adults and 35 children) with chronic idiopathic thrombocytopenic purpura (ITP) and a platelet count of < 50 x 10(9)/L treated with dapsone at a dose of 1-2 mg/kg/d are presented. A response was observed in 57 (63.3%) patients. The average time for response was 3.5 months (range 1-9) and the average duration of treatment with dapsone was 10.4 months (range 4-14). Overall response rates of 65.7% and 61.8% were observed in children and adults respectively. Side effects requiring discontinuation of therapy were observed in three (2%) patients. These results demonstrate that dapsone is an effective, inexpensive and well-tolerated treatment for chronic ITP, in both children and adults and could be considered for patients who fail steroid therapy.

引用

页码：328 / 331

页数：4

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