Uncovering New Functions for MicroRNAs in Caenorhabditis elegans

被引：30

作者：

Abbott, Allison L. ^{[1
]}

机构：

[1] Marquette Univ, Dept Biol Sci, Milwaukee, WI 53201 USA

来源：

CURRENT BIOLOGY | 2011年 / 21卷 / 17期

关键词：

C-ELEGANS; LIFE-SPAN; TARGETS; EXPRESSION; PREDICTION; MIR-84; FAMILY; GENES;

D O I：

10.1016/j.cub.2011.07.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the nematode Caenorhabditis elegans, microRNA (miRNA) regulation of development was first observed in the striking abnormalities of lin-4 and let-7 loss of function mutants. However, after these first two miRNA mutant phenotypes were described, progress on the identification of miRNA functions in worms slowed considerably. Recent advances reveal new functions for miRNAs in embryonic and larval development as well as in the regulation of lifespan and stress response. Results from a combination of computational, biochemical, and genetic approaches have deepened our understanding of miRNA regulation of target mRNAs and support the hypothesis that miRNAs have an important role in ensuring the robustness of developmental and physiological pathways.

引用

页码：R668 / R671

页数：4

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