The Role of Natural Killer Cells in Sepsis

被引：75

作者：

Chiche, Laurent ^{[1
,2
,3
,4
,5
]}

Forel, Jean-Marie ^{[5
,6
]}

Thomas, Guillemette ^{[4
,5
]}

Farnarier, Catherine ^{[4
]}

Vely, Frederic ^{[4
]}

Blery, Mathieu ^{[7
]}

Papazian, Laurent ^{[5
,6
]}

Vivier, Eric ^{[1
,2
,3
,4
]}

机构：

[1] Univ Mediterranee UM 631, CIML, F-13288 Marseille, France

[2] INSERM UMR S 631, Marseille, France

[3] CNRS, UMR 6102, Marseille, France

[4] Hop Conception, Assistance Publ Hop Marseille, Immunol Lab, F-13385 Marseille 5, France

[5] Hop Nord Marseille, Assistance Publ Hop Marseille, F-13915 Marseille 20, France

[6] Univ Aix Marseille 2, Unite Rech Malad Infect & Trop URMITE, CNRS, UMR 6236, F-13284 Marseille 07, France

[7] Innate Pharma, F-13276 Marseille 09, France

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年

基金：

欧洲研究理事会;

关键词：

HUMAN NK CELLS; ACTIVE CYTOMEGALOVIRUS-INFECTION; SEPTIC SHOCK; INFLAMMATORY RESPONSE; MURINE MODEL; CD8(+) T; MACROPHAGES; INNATE; RECOGNITION; ACTIVATION;

D O I：

10.1155/2011/986491

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Severe sepsis and septic shock are still deadly conditions urging to develop novel therapies. A better understanding of the complex modifications of the immune system of septic patients is needed for the development of innovative immunointerventions. Natural killer (NK) cells are characterized as CD3(-)NKp46(+)CD56(+) cells that can be cytotoxic and/or produce high amounts of cytokines such as IFN-gamma. NK cells are also engaged in crosstalks with other immune cells, such as dendritic cells, macrophages, and neutrophils. During the early stage of septic shock, NK cells may play a key role in the promotion of the systemic inflammation, as suggested in mice models. Alternatively, at a later stage, NK cells-acquired dysfunction could favor nosocomial infections and mortality. Standardized biological tools defining patients' NK cell status during the different stages of sepsis are mandatory to guide potential immuno-interventions. Herein, we review the potential role of NK cells during severe sepsis and septic shock.

引用

页数：8

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