Kainate receptors: knocking out plasticity

被引：20

作者：

Huettner, JE ^{[1
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO 63110 USA

来源：

TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 07期

关键词：

D O I：

10.1016/S0166-2236(00)01830-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There is increasing evidence that kainate receptors contribute to both postsynaptic and presynaptic signaling. Studies of knockout mice have played a pivotal role in defining the functions of kainate receptors, including a recent study that implicates kainate receptors in frequency-dependent facilitation and long-term potentiation of hippocampal mossy fiber synapses.

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页码：365 / 366

页数：2

相关论文

共 23 条

[1] Kainate receptors are involved in synaptic plasticity [J].

Bortolotto, ZA ;

Clarke, VRJ ;

Delany, CM ;

Parry, MC ;

Smolders, I ;

Vignes, M ;

Ho, KH ;

Miu, P ;

Brinton, BT ;

Fantaske, R ;

Ogden, A ;

Gates, M ;

Ornstein, PL ;

Lodge, D ;

Bleakman, D ;

Collingridge, GL .

NATURE, 1999, 402 (6759) :297-301

[2]

Bureau I, 1999, J NEUROSCI, V19, P653

[3] Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons [J].

Castillo, PE ;

Malenka, RC ;

Nicoll, RA .

NATURE, 1997, 388 (6638) :182-186

[4] Kainate receptors: subunits, synaptic localization and function [J].

Chittajallu, R ;

Braithwaite, SP ;

Clarke, VRJ ;

Henley, JM .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (01) :26-35

[5] Regulation of glutamate release by presynaptic kainate receptors in the hippocampus [J].

Chittajallu, R ;

Vignes, M ;

Dev, KK ;

Barnes, JM ;

Collingridge, GL ;

Henley, JM .

NATURE, 1996, 379 (6560) :78-81

[6] A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission [J].

Clarke, VRJ ;

Ballyk, BA ;

Hoo, KH ;

Mandelzys, A ;

Pellizzari, A ;

Bath, CP ;

Thomas, J ;

Sharpe, EF ;

Davies, CH ;

Ornstein, PL ;

Schoepp, DD ;

Kamboj, RK ;

Collingridge, GL ;

Lodge, D ;

Bleakman, D .

NATURE, 1997, 389 (6651) :599-603

[7] Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus [J].

Contractor, A ;

Swanson, GT ;

Sailer, A ;

O'Gorman, S ;

Heinemann, SF .

JOURNAL OF NEUROSCIENCE, 2000, 20 (22) :8269-8278

[8] Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus [J].

Contractor, A ;

Swanson, G ;

Heinemann, SF .

NEURON, 2001, 29 (01) :209-216

[9] GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells [J].

Cossart, R ;

Esclapez, M ;

Hirsch, JC ;

Bernard, C ;

Ben-Ari, Y .

NATURE NEUROSCIENCE, 1998, 1 (06) :470-478

[10] Synaptic kainate receptors [J].

Frerking, M ;

Nicoll, RA .

CURRENT OPINION IN NEUROBIOLOGY, 2000, 10 (03) :342-351