Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells

被引：28

作者：

Rosenblat, Gennady

Meretski, Shai

Segal, Joseph

Tarshis, Mark ^{[1
]}

Schroeder, Avi

Zanin-Zhorov, Alexandra

Lion, Gilead ^{[2
]}

Ingber, Arieh ^{[2
]}

Hochberg, Malka ^{[2
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Med, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Dermatol, IL-91120 Jerusalem, Israel

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2011年 / 303卷 / 04期

关键词：

UVB; Photodamage; UVB-damaged cells; Non-sunscreen protection; Avocado extract; Polyhydroxylated fatty alcohols; ULTRAVIOLET-RADIATION; PHOTOPROTECTION; KERATINOCYTES; INTERLEUKIN-6; CONSTITUENTS; REPAIR; DEATH;

D O I：

10.1007/s00403-010-1088-6

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE(2), and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-protective agent in UV-induced skin damage.

引用

页码：239 / 246

页数：8

共 36 条

[1] Trypanocidal constituents in plants 5.: Evaluation of some Mexican plants for their trypanocidal activity and active constituents in the seeds of Persea americana [J].