Non-invasive fetal sex determination: Impact on clinical practice

被引：72

作者：

Finning, Kirstin M. ^{[2
]}

Chitty, Lyn S. ^{[1
,3
]}

机构：

[1] Inst Child Hlth, Dept Clin & Mol Genet, London WC1N 1EH, England

[2] Int Blood Grp Reference Lab, Bristol, Avon, England

[3] UCL Hosp, NHS Fdn Trust, Fetal Med Unit, London, England

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2008年 / 13卷 / 02期

关键词：

fetalsex determination; free fetal DNA; non-invasive prenatal diagnosis;

D O I：

10.1016/j.siny.2007.12.007

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Prenatal fetal sex determination is undertaken in women at high risk of serious genetic disorders affecting a specific sex. Traditionally, this is undertaken by invasive testing, usually chorionic villus sampling, which carries a risk of miscarriage of around 1%. The identification of cell-free fetal DNA in the maternal circulation has allowed the development of 'non-invasive prenatal diagnostic tests', which permit fetal sex determination without risk to the pregnancy. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：69 / 75

页数：7

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