SOX15 transcriptionally increases the function of AOC1 to modulate ferroptosis and progression in prostate cancer

被引：29

作者：

Ding, Yinghui ^{[1
]}

Feng, Yuankang ^{[1
]}

Huang, Zhenlin ^{[1
]}

Zhang, Yu ^{[1
]}

Li, Xiang ^{[1
]}

Liu, Ruoyang ^{[1
]}

Li, Hao ^{[1
]}

Wang, Tao ^{[1
]}

Ding, Yafei ^{[1
]}

Jia, Zhankui ^{[1
]}

Yang, Jinjian ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Urol, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China

来源：

CELL DEATH & DISEASE | 2022年 / 13卷 / 08期

关键词：

AMILORIDE-BINDING-PROTEIN; AMINE OXIDASE; SPERMIDINE; CELLS; GENE; PROLIFERATION; COPPER;

D O I：

10.1038/s41419-022-05108-w

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Amine oxidase copper-containing 1 (AOC1) is considered an oncogene in many types of tumors. Nevertheless, there have been no investigations of AOC1 and its regulatory mechanism in prostate cancer. Here, we reveal a novel action of AOC1 and a tumor suppressor mechanism in prostate cancer. AOC1 is downregulated in prostate cancer. Abatement of AOC1 in prostate cancer tissue is positively correlated with the tumor size, lymph node metastasis, and Gleason score for prostate cancer. Conversely, high expression of AOC1 is significantly associated with reduced proliferation and migration in prostate cancer both in vitro and in vivo. We show that the anticancer effect of AOC1 is mediated by its action on spermidine which leads to the activation of reactive oxygen species and ferroptosis. AOC1 expression in prostate cancer is positively regulated by the transcription factor SOX15. Therefore, SOX15 can transcriptionally promote AOC1 expression and strengthen this effect. Targeting AOC1 and SOX15 may be promising for the treatment of prostate cancer.

引用

页数：13

共 35 条

[1] Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy [J].

Affronti, Hayley C. ;

Rowsam, Aryn M. ;

Pellerite, Anthony J. ;

Rosario, Spencer R. ;

Long, Mark D. ;

Jacobi, Justine J. ;

Bianchi-Smiraglia, Anna ;

Boerlin, Christoph S. ;

Gillard, Bryan M. ;

Karasik, Ellen ;

Foster, Barbara A. ;

Moser, Michael ;

Wilton, John H. ;

Attwood, Kristopher ;

Nikiforov, Mikhail A. ;

Azabdaftari, Gissou ;

Pili, Roberto ;

Phillips, James G. ;

Casero, Robert A., Jr. ;

Smiraglia, Dominic J. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[2] HUMAN KIDNEY AMILORIDE-BINDING PROTEIN - CDNA STRUCTURE AND FUNCTIONAL EXPRESSION [J].

BARBRY, P ;

CHAMPE, M ;

CHASSANDE, O ;

MUNEMITSU, S ;

CHAMPIGNY, G ;

LINGUEGLIA, E ;

MAES, P ;

FRELIN, C ;

TARTAR, A ;

ULLRICH, A ;

LAZDUNSKI, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7347-7351

[3] A Small Molecule Polyamine Oxidase Inhibitor Blocks Androgen-Induced Oxidative Stress and Delays Prostate Cancer Progression in the Transgenic Adenocarcinoma of the Mouse Prostate Model [J].

Basu, Hirak S. ;

Thompson, Todd A. ;

Church, Dawn R. ;

Clower, Cynthia C. ;

Mehraein-Ghomi, Farideh ;

Amlong, Corey A. ;

Martin, Christopher T. ;

Woster, Patrick M. ;

Lindstrom, Mary J. ;

Wilding, George .

CANCER RESEARCH, 2009, 69 (19) :7689-7695

[4] PLASMA SPERMIDINE CONCENTRATIONS IN PATIENTS WITH TUMORS OF THE BREAST OR PROSTATE OR TESTIS [J].

CHAISIRI, P ;

HARPER, ME ;

BLAMEY, RW ;

PEELING, WB ;

GRIFFITHS, K .

CLINICA CHIMICA ACTA, 1980, 104 (03) :367-375

[5]

CHASSANDE O, 1994, J BIOL CHEM, V269, P14484

[6] Copper amine oxidase: cunning cofactor and controversial copper [J].

Dawkes, HC ;

Phillips, SEV .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2001, 11 (06) :666-673

[7] Evolution and functional classification of mammalian copper amine oxidases [J].

de Carvalho, Leonor Lopes ;

Bligt-Linden, Eva ;

Ramaiah, Arunachalam ;

Johnson, Mark S. ;

Salminen, Tiina A. .

MOLECULAR PHYLOGENETICS AND EVOLUTION, 2019, 139

[8] Immunotherapy of prostate cancer: should we be targeting stem cells and EMT? [J].

Dunning, Naomi L. ;

Laversin, Stephanie A. ;

Miles, Amanda K. ;

Rees, Robert C. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2011, 60 (08) :1181-1193

[9] Dietary spermidine for lowering high blood pressure [J].

Eisenberg, Tobias ;

Abdellatif, Mahmoud ;

Zimmermann, Andreas ;

Schroeder, Sabrina ;

Pendl, Tobias ;

Harger, Alexandra ;

Stekovic, Slaven ;

Schipke, Julia ;

Magnes, Christoph ;

Schmidt, Albrecht ;

Ruckenstuhl, Christoph ;

Dammbrueck, Christopher ;

Gross, Angelina S. ;

Herbst, Viktoria ;

Carmona-Gutierrez, Didac ;

Pietrocola, Federico ;

Pieber, Thomas R. ;

Sigrist, Stephan J. ;

Linke, Wolfgang A. ;

Muehlfeld, Christian ;

Sadoshima, Junichi ;

Dengjel, Joern ;

Kiechl, Stefan ;

Kroemer, Guido ;

Sedej, Simon ;

Madeo, Frank .

AUTOPHAGY, 2017, 13 (04) :767-769

[10] Spermidine as a target for cancer therapy [J].

Fan, Jingjing ;

Feng, Ziyuan ;

Chen, Ning .

PHARMACOLOGICAL RESEARCH, 2020, 159

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