Progress of succinic acid production from renewable resources: Metabolic and fermentative strategies

被引：116

作者：

Jiang, Min ^{[1
,2
]}

Ma, Jiangfeng ^{[1
,2
]}

Wu, Mingke ^{[1
]}

Liu, Rongming ^{[1
,3
]}

Liang, Liya ^{[1
,3
]}

Xin, Fengxue ^{[1
]}

Zhang, Wenming ^{[2
]}

Jia, Honghua ^{[1
,2
]}

Dong, Weiliang ^{[1
]}

机构：

[1] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Coll Biotechnol & Pharmaceut Engn, Nanjing 211800, Jiangsu, Peoples R China

[2] Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing 211800, Jiangsu, Peoples R China

[3] Univ Colorado Boulder, RASEI, 4001 Discovery Dr Suite N321, Boulder, CO 80309 USA

来源：

BIORESOURCE TECHNOLOGY | 2017年 / 245卷

关键词：

Succinic acid; Renewable resources; Metabolic engineering; NADH/NAD(+); Carbon dioxide; ESCHERICHIA-COLI; ACTINOBACILLUS-SUCCINOGENES; PYRUVATE-CARBOXYLASE; MANNHEIMIA-SUCCINICIPRODUCENS; SACCHAROMYCES-CEREVISIAE; ANAEROBIOSPIRILLUM-SUCCINICIPRODUCENS; PHOSPHOENOLPYRUVATE CARBOXYLASE; BIOTECHNOLOGICAL PRODUCTION; CORYNEBACTERIUM-GLUTAMICUM; EFFICIENT PRODUCTION;

D O I：

10.1016/j.biortech.2017.05.209

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Succinic acid is a four-carbon dicarboxylic acid, which has attracted much interest due to its abroad usage as a precursor of many industrially important chemicals in the food, chemicals, and pharmaceutical industries. Facing the shortage of crude oil supply and demand of sustainable development, biological production of succinic acid from renewable resources has become a topic of worldwide interest. In recent decades, robust producing strain selection, metabolic engineering of model strains, and process optimization for succinic acid production have been developed. This review provides an overview of succinic acid producers and cultivation technology, highlight some of the successful metabolic engineering approaches. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：1710 / 1717

页数：8

共 83 条

[51] A new process for the continuous production of succinic acid from glucose at high yield, titer, and productivity [J].