Tenascin-C Signaling in melanoma

被引：25
作者：
Shao, Hanshuang [1 ]
Kirkwood, John M. [2 ]
Wells, Alan [1 ,3 ]
机构：
[1] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15260 USA
[2] Univ Pittsburgh, Inst Canc, Med & Dermatol & Translat Sci Melanoma Program, Pittsburgh, PA USA
[3] Pittsburgh VA Hlth Syst, Lab & Pathol Serv, Pittsburgh, PA USA
来源：
CELL ADHESION & MIGRATION | 2015年 / 9卷 / 1-2期
基金：
美国国家卫生研究院;
关键词：
invasion; melanoma; survival; Tenascin-C; EPIDERMAL-GROWTH-FACTOR; FACTOR RECEPTOR; STEM-CELLS; EGF RECEPTOR; TUMOR-CELLS; EXPRESSION; CANCER; MIGRATION; ACTIVATION; FIBROBLASTS;
D O I：
10.4161/19336918.2014.972781
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tenascin-C (TNC), a multifunctional matricellular glyco-protein, is highly expressed in the majority of melanoma cell lines and has been implicated in the progression of melanoma. A growing body of evidence has implicated the role of TNC in the process of invasion and metastasis for melanoma. However, the mechanism and individual signaling pathways by which TNC drives melanoma progression have not been illuminated. Herein we provide perspectives from the investigation of TNC in other settings that may hint at the mechanistic role of TNC in this disease.
引用
收藏
页码：125 / 130
页数：6
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