SYNTHESIS OF BIOLOGICALLY ACTIVE-3-AMINO-2-(1,3,4-OXADIAZOLYL, 1,3,4-THIADIAZOLYL AND 1,2,4-TRIAZOLYL) NAPHTHO [2,1-b] FURANS

Hydroxynaphthonitrile (4), was prepared by cyclizing hydroxynaphthaldoxime (3). The compound (4) was reacted with ethyl chloroacetate to get a condensed product (5) which was cyclized into ethyl 3-aminonaphtho [2,1-b] furan-2-carboxylate (6). The treatment of ester (6) with hydrazine hydrate resulted in the formation of-hydrazide (7), where it was further condensed with various isothiocyanates to get 3-aminonaphtho [2,1-b] furan (epsilon-arylamino)-2-carbothiosemicarbazides (8a-e). The semicarbazides 8 were cyclized into title compounds. using different methods. The newly synthesized compounds were characterized by analytical and spectral data. They were subjected to the antimicrobial screening. Some of them gave encouraging activity.