PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathway in vitro

被引：27

作者：

Zhang, Ke ^{[1
]}

Ye, Chun ^{[1
]}

Zhou, Qin ^{[1
]}

Zheng, Ron ^{[1
]}

Lv, Xiaoyan ^{[1
]}

Chen, Ye ^{[1
]}

Hu, Zhongguo ^{[1
]}

Guo, Hong ^{[1
]}

Zhang, Zheng ^{[1
]}

Wang, Yidong ^{[1
]}

Tan, Ruizhi ^{[1
]}

Liu, Yuhang ^{[1
]}

机构：

[1] Sichuan Univ, Sch Life Sci, W China Med Sch, State Key Lab Biotherapy & Canc Ctr, Chengdu 610041, Peoples R China

来源：

CELL BIOCHEMISTRY AND FUNCTION | 2007年 / 25卷 / 06期

关键词：

PKD1; gene; cell migration; invasion; Wnt signaling pathway;

D O I：

10.1002/cbf.1417

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The similar to 14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a large (similar to 460 kDa) protein, termed polycystin-1 (PC-1), that is responsible for autosomal dominant polycystic kidney disease (ADPKD). The unique organization of its multiple adhesive domains (16 Ig-like domains/PKD domains) suggests that it may play an important role in cell-cell/cell-matrix interactions. Here we demonstrated that PKD1 promoted cell-cell and cell-matrix interactions in cancer cells, indicating that PC-1 is involved in the cell adhesion process. Furthermore in this study, we showed that PKD1 inhibited cancer cells migration and invasion. And we also showed that PC-1 regulated these processes in a process that may be at least partially through the Wnt pathway. Collectively, our data suggest that PKD1 may act as a novel member of the tumor suppressor family of genes. Copyright (C) 2007 John Wiley & Sons, Ltd.

引用

页码：767 / 774

页数：8

共 32 条

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