Mucinous adenocarcinoma of the lung in association with congenital pulmonary airway malformation

被引：42

作者：

Summers, Ryan J.

Shehata, Bahig M. ^{[4
]}

Bleacher, John C. ^{[5
]}

Stockwell, Christina

Rapkin, Louis ^{[1
,2
,3
]}

机构：

[1] Childrens Healthcare Atlanta, Aflac Canc Ctr, Atlanta, GA 30322 USA

[2] Childrens Healthcare Atlanta, Blood Disorders Serv, Atlanta, GA 30322 USA

[3] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30322 USA

[4] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA

[5] Childrens Healthcare Atlanta Scottish Rite, Dept Pediat Surg, Atlanta, GA 30342 USA

来源：

JOURNAL OF PEDIATRIC SURGERY | 2010年 / 45卷 / 11期

关键词：

Mucinous Adenocarcinoma; Congenital pulmonary airway malformation (CPAM); KRAS; CYSTIC ADENOMATOID MALFORMATION; EPIDERMAL-GROWTH-FACTOR; BRONCHIOLOALVEOLAR CARCINOMA; PLEUROPULMONARY BLASTOMA; KRAS MUTATIONS; CANCER; MANAGEMENT; RHABDOMYOSARCOMA; CLASSIFICATION; CHEMOTHERAPY;

D O I：

10.1016/j.jpedsurg.2010.07.008

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Congenital pulmonary airway malformation (CPAM) is a rare developmental abnormality of the lung that has been associated with the presence of rhabdomyosarcoma, pleuropulmonary blastoma, and most commonly bronchioalveolar carcinoma (BAC) of the lung. Here, we report the case of an 8-year-old patient who developed KRAS mutation positive stage IV mucinous adenocarcinoma of the lung in association with CPAM. This case reflects the previously recognized progression of CPAM to malignancy and suggests that BAC arising in CPAM may take a more aggressive course than previously recognized.(C) 2010 Elsevier Inc. All rights reserved.

引用

页码：2256 / 2259

页数：4

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