Mucinous adenocarcinoma of the lung in association with congenital pulmonary airway malformation

被引：41

作者：

Summers, Ryan J.

Shehata, Bahig M. ^{[4
]}

Bleacher, John C. ^{[5
]}

Stockwell, Christina

Rapkin, Louis ^{[1
,2
,3
]}

机构：

[1] Childrens Healthcare Atlanta, Aflac Canc Ctr, Atlanta, GA 30322 USA

[2] Childrens Healthcare Atlanta, Blood Disorders Serv, Atlanta, GA 30322 USA

[3] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30322 USA

[4] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA

[5] Childrens Healthcare Atlanta Scottish Rite, Dept Pediat Surg, Atlanta, GA 30342 USA

来源：

JOURNAL OF PEDIATRIC SURGERY | 2010年 / 45卷 / 11期

关键词：

Mucinous Adenocarcinoma; Congenital pulmonary airway malformation (CPAM); KRAS; CYSTIC ADENOMATOID MALFORMATION; EPIDERMAL-GROWTH-FACTOR; BRONCHIOLOALVEOLAR CARCINOMA; PLEUROPULMONARY BLASTOMA; KRAS MUTATIONS; CANCER; MANAGEMENT; RHABDOMYOSARCOMA; CLASSIFICATION; CHEMOTHERAPY;

D O I：

10.1016/j.jpedsurg.2010.07.008

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Congenital pulmonary airway malformation (CPAM) is a rare developmental abnormality of the lung that has been associated with the presence of rhabdomyosarcoma, pleuropulmonary blastoma, and most commonly bronchioalveolar carcinoma (BAC) of the lung. Here, we report the case of an 8-year-old patient who developed KRAS mutation positive stage IV mucinous adenocarcinoma of the lung in association with CPAM. This case reflects the previously recognized progression of CPAM to malignancy and suggests that BAC arising in CPAM may take a more aggressive course than previously recognized.(C) 2010 Elsevier Inc. All rights reserved.

引用

页码：2256 / 2259

页数：4

共 33 条

[1] [Anonymous], 2004, Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs
[2] [Anonymous], 101 ANN M AM ASS CAN
[3] Embryonal rhabdomyosarcoma of the lung arising in cystic adenomatoid malformation: Case report and review of the literature
dAgostino, S
Bonoldi, E
Dante, S
Meli, S
Cappellari, F
Musi, L
[J]. JOURNAL OF PEDIATRIC SURGERY, 1997, 32 (09) : 1381 - 1383
[4] Primary rhabdomyosarcoma of the lung arising over cystic pulmonary adenomatoid malformation
Doladzas, T
Arvelakis, A
Karavokyros, IG
Gougoudi, E
Pikoulis, E
Patsouris, E
Michail, PO
[J]. PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2005, 22 (06) : 525 - 529
[5] Pleuropulmonary blastoma in congenital cystic adenomatoid malformation:: Report of a case
Federici, S
Domenichelli, V
Tani, G
Sciutti, R
Burnelli, R
Zanetti, G
Dòmini, R
[J]. EUROPEAN JOURNAL OF PEDIATRIC SURGERY, 2001, 11 (03) : 196 - 199
[6] Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features
Finberg, Karin E.
Sequist, Lecia V.
Joshi, Victoria A.
Muzikansky, Alona
Miller, Julie M.
Han, Moonjoo
Beheshti, Javad
Chirieac, Lucian R.
Mark, Eugene J.
Iafrate, A. John
[J]. JOURNAL OF MOLECULAR DIAGNOSTICS, 2007, 9 (03) : 320 - 326
[7] Granata C, 1998, PEDIATR PULM, V25, P62, DOI 10.1002/(SICI)1099-0496(199801)25:1<62::AID-PPUL8>3.0.CO
[8] 2-Q
[9] Expression of epidermal growth factor, receptor, but not K-RAS mutations, is present in congenital cystic airway malformation/congenital pulmonary airway malformation
Guo, Hua
Cajaiba, Mariana M.
Borys, Dariusz
Gutierrez, Maria C.
Yee, Herman
Drut, Rosa M.
Drut, Ricardo
Askin, Frederic
Reyes-Mugica, Miguel
Greco, M. Alba
[J]. HUMAN PATHOLOGY, 2007, 38 (12) : 1772 - 1778
[10] Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
Hanna, N
Shepherd, FA
Fossella, FV
Pereira, JR
De Marinis, F
von Pawel, J
Gatzemeier, U
Tsao, TCY
Pless, M
Muller, T
Lim, HL
Desch, C
Szondy, K
Gervais, R
Shaharyar
Manegold, C
Paul, S
Paoletti, P
Einhorn, L
Bunn, PA
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (09) : 1589 - 1597

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