One-pot synthesis of 1,3-thiazolidin-4-ones derivatives from 2-amino-1,3,4-thiadiazole

被引：6

作者：

Cunico, Wilson ^{[1
]}

Gornes, Claudia R. B. ^{[1
]}

Ferreira, Maria de Lourdes G. ^{[1
]}

Capri, Liliane R. ^{[1
]}

Santos, Margareth R. L. ^{[1
]}

Sa, Paula M. ^{[1
]}

Boechat, Nubia ^{[1
]}

Bastos, Monica M. ^{[1
]}

Maciel, Lindalva C. ^{[1
]}

Mayer, Lucia M. U. ^{[1
]}

机构：

[1] Fiocruz MS, Inst Tecnol Farmacos Farmanguinhos, BR-21041250 Rio De Janeiro, Brazil

来源：

LETTERS IN ORGANIC CHEMISTRY | 2007年 / 4卷 / 07期

关键词：

4-thiazolidinone; heterocycles; cyclocondensation;

D O I：

10.2174/157017807782006245

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several 1,3-thiazolidin-4-ones were synthesized by cyclocondensation reaction of 2-amino-1,3,4-thiadiazole, mercaptoacetic acid and various arenealdehydes in moderate to good yields. These compounds were characterized by I H, C-13 and F-19 NMR. The antimalarial activity of thiazolidinones was evaluated in vitro against Plasmodium falciparum clone but none of them showed activity at maximum concentration (50 mu g/ml) used.

引用

页码：505 / 508

页数：4

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