Treatment of a double nonunion of the femur by rhBMP-2

被引:12
作者
Alt, Volker [1 ]
Meyer, Christof [1 ]
Litzlbauer, Horst Detlef [2 ]
Schnettler, Reinhard [1 ]
机构
[1] Univ Hosp Giessen Marburg, Dept Trauma Surg, D-35385 Giessen, Germany
[2] Univ Hosp Giessen Marburg, Dept Diagnost Radiol, Giessen, Germany
关键词
bone morphogenetic protein; BMP-2; nonunion; femur; fracture;
D O I
10.1097/BOT.0b013e3181589700
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
A 49-year-old patient sustained an ipsilateral fracture of the lateral femoral neck and distal femoral shaft, which were treated with a long intramedullary nail with a hip screw component. Both fractures did not heal, and both nonunion sites were revised by reosteosynthesis with a dynamic hip screw for the femoral neck and a locked intramedullary nail for the shaft region combined with autogenous bone grafting at both sites. At 14 months from injury and after 2 operations, both nonunions persisted. At a third surgery, I kit of recombinant human bone morphogenetic protein-2 (rhBMP-2) on an absorbable collagen sponge was applied to each site, without any modification of the osteosynthesis or additional bone grafting. The lateral femoral neck and the femoral shaft consolidated 24 and 30 weeks, respectively, after the rhBMP-2 application, and the patient resumed his work as industrial worker after 7 months after his last surgery. We believe this is the first study to report the successful use of 2 kits of rhBMP-2 in a double nonunion of the femur.
引用
收藏
页码:734 / 737
页数:4
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