Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses

被引:8
作者
Ertesvag, Nina Urke [1 ]
Cox, Rebecca Jane [1 ,2 ]
Lartey, Sarah Larteley [1 ]
Mohn, Kristin G-, I [1 ,3 ]
Brokstad, Karl Albert [1 ]
Trieu, Mai-Chi [1 ]
机构
[1] Univ Bergen, Influenza Ctr, Dept Clin Sci, Bergen, Norway
[2] Haukeland Hosp, Dept Microbiol, Bergen, Norway
[3] Haukeland Hosp, Dept Med, Bergen, Norway
基金
欧盟地平线“2020”;
关键词
PROTECTION; VACCINES; METAANALYSIS; INFECTION; RESPONSES; EFFICACY; A(H3N2); HISTORY; DESIGN; IMPACT;
D O I
10.1038/s41541-022-00490-0
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
History of influenza A/H3N2 exposure, especially childhood infection, shape antibody responses after influenza vaccination and infection, but have not been extensively studied. We investigated the breadth and durability of influenza A/H3N2-specific hemagglutinin-inhibition antibodies after live-attenuated influenza vaccine in children (aged 3-17 years, n = 42), and after inactivated influenza vaccine or infection in adults (aged 22-61 years, n = 42) using 14 antigenically distinct A/H3N2 viruses circulating from 1968 to 2018. We found that vaccination and infection elicited cross-reactive antibody responses, predominantly directed against newer or future strains. Childhood H3-priming increased the breadth and magnitude of back-boosted A/H3N2-specific antibodies in adults. Broader and more durable A/H3N2-specific antibodies were observed in repeatedly vaccinated adults than in children and previously unvaccinated adults. Our findings suggest that early A/H3N2 exposure and frequent seasonal vaccination could increase the breadth and seropositivity of antibody responses, which may improve vaccine protection against future viruses.
引用
收藏
页数:10
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