T cell homeostasis: Keeping useful T cells alive and live T cells useful

被引：101

作者：

Jameson, SC ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Ctr Immunol, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

来源：

SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 03期

关键词：

memory T cells; naive T cells; cytokines; TCR; peptide/MHC;

D O I：

10.1016/j.smim.2005.02.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It has become clear that the regulation of T cell numbers is under peripheral homeostatic control. However, the rules for homeostasis vary with the T cells' differentiation state and the overall T cell number in the animal. Furthermore, homeostatic pressures can cause unexpected changes in T cell differentiation and function which might promote or dampen T cell reactivity. In this review, we focus on the role of peptide/MHC and cytokine interactions in regulating the size and composition of the T cell pool. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：231 / 237

页数：7

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