Application of DNA markers to clinical genetics

被引：18

作者：

Nakamura, Y

机构：

[1] Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108

来源：

JAPANESE JOURNAL OF HUMAN GENETICS | 1996年 / 41卷 / 01期

关键词：

RFLP; VNTR; linkage analysis; positional cloning; APC;

D O I：

10.1007/BF01892620

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA technology using DNA sequence polymorphisms has brought a new system to the fields of medicine and forensic science, especially for the studies of genetic diseases and tumor suppressor genes, and for identification of individuals for forensic purposes. Linkage analysis based on segregation of polymorphic alleles in affected families has contributed to identification of many genetic diseases. We isolated a large number of polymorphic DNA markers, called VNTR (variable number of tandem repeat) markers and identified the APC gene that is responsible for familial adenomatous polyposis (FAP) by means of a so-called ''positional cloning'' and characterized germline and somatic mutations of the APC gene in colorectal cancer patients. In addition, we have applied genetic information during colorectal carcinogenesis to sensitive diagnosis of lymph-node metastasis of colorectal cancer.

引用

页码：1 / 10

页数：10

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