Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists

被引：53

作者：

Vu, CB ^{[1
]}

Pan, D ^{[1
]}

Peng, B ^{[1
]}

Kumaravel, G ^{[1
]}

Smits, G ^{[1
]}

Jin, XW ^{[1
]}

Phadke, D ^{[1
]}

Engber, T ^{[1
]}

Huang, C ^{[1
]}

Reilly, J ^{[1
]}

Tam, S ^{[1
]}

Grant, D ^{[1
]}

Hetu, G ^{[1
]}

Petter, RC ^{[1
]}

机构：

[1] Biogen Idec Inc, Dept Med Chem, Cambridge, MA 02142 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 48卷 / 06期

关键词：

D O I：

10.1021/jm0498396

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine have recently been demonstrated to be potent and selective adenosine A(2a) receptor antagonists with oral activity in rodent models of Parkinson's disease. We have replaced the piperazinyl group with a variety of linear, monocyclic, and bicyclic diamines. Of these diamines, (R)-2-(aminomethyl)pyrrolidine is a particularly potent and selective replacement for the piperazinyl group. With this diamine component, we have been able to prepare numerous analogues with low nanomolar affinity toward the A(2a) receptor and good selectivity with respect to the A(1) receptor (> 200-fold in some cases). Selected analogues from this series of [1,2,4]triazolo[1,5-a][1,3,5]triazine have now been shown to be orally active in the mouse catalepsy model.

引用

页码：2009 / 2018

页数：10

共 38 条

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