Purpose: We aimed to evaluate the predictive ability of an integrated score based on several inflammatory indices of acute kidney injury (AKI) in patients in the intensive care unit (ICU). Patients and Methods: In this observational study, 2555 patients from the Medical Information Mart for Intensive Care III database were randomly assigned to the test set (n=1599) and internal validation set (n=656). Moreover, 412 coronary care unit patients from Zhongnan Hospital, Wuhan University were also included in the external validation set. The AKI-specific inflammatory index (ASII) was created using various inflammatory indices significantly associated with AKI. We further developed and validated two nomograms based on the ASII and other informative clinical features of AKI and prognosis. Results: The ASII was calculated as 2.317xMLR+0.417xGPS+0.007xALRI. In the training set, patients with a high ASII had a higher risk of incident AKI (odds ratio [OR], 5.33; 95% confidence index [CI], 3.60-7.88; P<0.001) than those with a low ASII with or without preexisting chronic kidney disease. The nomograms for AKI and prognosis based on the ASII and other significant clinical characteristics had high predictive value in the prediction of AKI and prognosis in patients in the ICU. Moreover, the results in the internal validation set and in the external validation cohort were almost consistent with those in the training set. Conclusion: The ASII is an AKI-specific tool based on the combination of available inflammatory indices. A high ASII is a strong predictor of a higher risk of AKI and worse survival outcomes in patients in the ICU.
机构:
Shaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, Israel
Abu Alfeilat, Mohsen
Slotki, Itzchak
论文数: 0引用数: 0
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Shaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, Israel
Slotki, Itzchak
Shavit, Linda
论文数: 0引用数: 0
h-index: 0
机构:
Shaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, Israel
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Alarcon Arias, Simone Costa
Valente, Carla Perez
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h-index: 0
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Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Valente, Carla Perez
Machado, Flavia Gomes
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h-index: 0
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Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Machado, Flavia Gomes
Fanelli, Camilla
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Fanelli, Camilla
Taemi Origassa, Clarice Silvia
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h-index: 0
机构:
Univ Sao Paulo, Fac Med, Immunol Lab, Div Nephrol, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Taemi Origassa, Clarice Silvia
de Brito, Thales
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Pathol, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
de Brito, Thales
Saraiva Camara, Niels Olsen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Immunol Lab, Div Nephrol, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Saraiva Camara, Niels Olsen
Avancini Costa Malheiros, Denise Maria
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h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Avancini Costa Malheiros, Denise Maria
Zatz, Roberto
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Zatz, Roberto
Fujihara, Clarice Kazue
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
机构:
Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USABrigham & Womens Hosp, Div Renal, Boston, MA 02115 USA
Bonventre, Joseph V.
Yang, Li
论文数: 0引用数: 0
h-index: 0
机构:
Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R ChinaBrigham & Womens Hosp, Div Renal, Boston, MA 02115 USA
机构:
George Washington Univ, Med Ctr, Dept Anesthesiol & Crit Care Med, Washington, DC 20037 USA
George Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USAGeorge Washington Univ, Med Ctr, Dept Anesthesiol & Crit Care Med, Washington, DC 20037 USA
Chawla, Lakhmir S.
Kimmel, Paul L.
论文数: 0引用数: 0
h-index: 0
机构:
George Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
NIDDKD, NIH, Bethesda, MD 20892 USAGeorge Washington Univ, Med Ctr, Dept Anesthesiol & Crit Care Med, Washington, DC 20037 USA
机构:
Shaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, Israel
Abu Alfeilat, Mohsen
Slotki, Itzchak
论文数: 0引用数: 0
h-index: 0
机构:
Shaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, Israel
Slotki, Itzchak
Shavit, Linda
论文数: 0引用数: 0
h-index: 0
机构:
Shaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Adult Nephrol Unit, Div Adult Nephrol, POB 3235, IL-91031 Jerusalem, Israel
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Alarcon Arias, Simone Costa
Valente, Carla Perez
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Valente, Carla Perez
Machado, Flavia Gomes
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Machado, Flavia Gomes
Fanelli, Camilla
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Fanelli, Camilla
Taemi Origassa, Clarice Silvia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Immunol Lab, Div Nephrol, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Taemi Origassa, Clarice Silvia
de Brito, Thales
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Pathol, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
de Brito, Thales
Saraiva Camara, Niels Olsen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Immunol Lab, Div Nephrol, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Saraiva Camara, Niels Olsen
Avancini Costa Malheiros, Denise Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Avancini Costa Malheiros, Denise Maria
Zatz, Roberto
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
Zatz, Roberto
Fujihara, Clarice Kazue
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Dept Clin Med, Renal Div,Lab Renal Pathophysiol LIM 16, Sao Paulo, Brazil
机构:
Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med, Boston, MA USABrigham & Womens Hosp, Div Renal, Boston, MA 02115 USA
Bonventre, Joseph V.
Yang, Li
论文数: 0引用数: 0
h-index: 0
机构:
Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R ChinaBrigham & Womens Hosp, Div Renal, Boston, MA 02115 USA
机构:
George Washington Univ, Med Ctr, Dept Anesthesiol & Crit Care Med, Washington, DC 20037 USA
George Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USAGeorge Washington Univ, Med Ctr, Dept Anesthesiol & Crit Care Med, Washington, DC 20037 USA
Chawla, Lakhmir S.
Kimmel, Paul L.
论文数: 0引用数: 0
h-index: 0
机构:
George Washington Univ, Med Ctr, Dept Med, Div Renal Dis & Hypertens, Washington, DC 20037 USA
NIDDKD, NIH, Bethesda, MD 20892 USAGeorge Washington Univ, Med Ctr, Dept Anesthesiol & Crit Care Med, Washington, DC 20037 USA