Neonatal lupus syndrome: Literature review

被引:26
作者
Morel, N. [1 ]
Georgin-Lavialle, S. [2 ]
Levesque, K. [3 ]
Guettrot-Imbert, G. [4 ]
Le Guern, V. [1 ]
Le Bidois, J. [5 ]
Bessieres, B. [6 ]
Brouzes, C. [7 ,8 ]
Le Mercier, D. [9 ]
Villain, E. [10 ]
Maltret, A. [10 ]
Costedoat-Chalumeau, N. [1 ]
机构
[1] Univ Paris 05, Hop Cochin, AP HP, Serv Med Interne Pole Med,Ctr Reference Malad Aut, F-75679 Paris 14, France
[2] Univ Paris 06, Hop Tenon, Serv Med Interne, F-75970 Paris 20, France
[3] Univ Montreal, CHU Ste Justine, Montreal, PQ H3T 1C5, Canada
[4] Univ Clermont Ferrand, Hop Gabriel Montpied, CHU Clermont Ferrand, Serv Med Interne, F-63003 Clermont Ferrand 1, France
[5] UE3C Unite Explorat Cardiol Cardiopathies Congeni, F-75015 Paris, France
[6] Univ Paris 05, CHU Necker Enfants Malad, Serv Histoembryol & Cytogenet, Unite Faetopathol, F-75015 Paris, France
[7] Univ Paris 05, Hop Necker Enfants Malad, Hematol Lab, F-75743 Paris 15, France
[8] Univ Paris 05, Hop Necker Enfants Malad, CNRS UMR8147, F-75743 Paris 15, France
[9] Univ Paris 05, CHU Necker Enfants Malad, Inserm UMR 781, Serv Gynecol Obstet, F-75015 Paris, France
[10] Univ Paris 05, CHU Necker Enfants Malad, Serv Cardiol Pediat, F-75015 Paris, France
来源
REVUE DE MEDECINE INTERNE | 2015年 / 36卷 / 03期
关键词
Neonatal lupus erythematosus; Congenital heart block; Anti-Ro/SSA antibodies; Anti-La/SSB antibodies; Sjogren's syndrome; Systemic lupus erythematosus; CONGENITAL HEART-BLOCK; MATERNAL ANTI-RO; QT INTERVAL PROLONGATION; CARDIAC MANIFESTATIONS; SSA/RO-SSB/LA; ATRIOVENTRICULAR-BLOCK; ELECTROCARDIOGRAPHIC ABNORMALITIES; INTRAVENOUS IMMUNOGLOBULIN; ENDOCARDIAL FIBROELASTOSIS; CUTANEOUS MANIFESTATIONS;
D O I
10.1016/j.revmed.2014.07.013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Neonatal lupus syndrome is associated with transplacental passage of maternal anti-SSA/Ro and anti-SSB/La antibodies. Children display cutaneous, hematological, liver or cardiac features. Cardiac manifestations include congenital heart block (CHB); endocardial fibroelastosis and dilated cardiomyopathy. The prevalence of CHB in newborns of anti-Ro/SSA positive women with known connective tissue disease is between 1 and 2% and the risk of recurrence is around 19%. Skin and systemic lesions are transient, whereas CHB is definitive and associated with significant morbidity and a mortality of 18%. A pacemaker must be implanted in 2/3 of cases. Myocarditis may be associated or appear secondly. Mothers of children with CHB are usually asymptomatic or display Sjogren's syndrome or undifferentiated connective tissue disease. In anti-Ro/SSA positive pregnant women, fetal echocardiography should be performed at least every 2 weeks from the 16th to 24th week gestation. An electrocardiogram should be performed for all newborn babies. The benefit of fluorinated corticosteroid therapy for CHB detected in utero remains unclear. Maternal use of hydroxychloroquine may be associated with a decreased recurrent CHB risk in a subsequent offspring. A prospective study is actually ongoing to confirm these findings. (C) 2014 Societe nationale francaise de medecine interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:159 / 166
页数:8
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