LRRK2 A419V Is Not Associated with Parkinson's Disease in Different Chinese Populations

被引：8

作者：

Wu, Yih Ru ^{[1
]}

Tan, Louis C. ^{[2
]}

Fu, Xiaoli ^{[3
]}

Chen, Chiung Mei ^{[1
]}

Au, Wing Lok ^{[2
]}

Chen, Ling ^{[3
]}

Chen, Yi Chun ^{[1
]}

Prakash, Kumar M. ^{[2
]}

Zheng, Yifan ^{[3
]}

Lee-Chen, Guey-Jen ^{[4
]}

Zhao, Yi ^{[2
]}

Zeng, Jin-Sheng ^{[3
]}

Tan, Eng King ^{[2
,5
]}

Pei, Zhong ^{[3
]}

机构：

[1] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Neurol, Taipei, Linkou, Taiwan

[2] Singapore Gen Hosp, Natl Inst Neurosci, Singapore 0316, Singapore

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou 510275, Guangdong, Peoples R China

[4] Natl Taiwan Normal Univ, Dept Life Sci, Taipei, Taiwan

[5] Duke Natl Univ Singapore, Grad Sch Med, Singapore, Singapore

来源：

PLOS ONE | 2012年 / 7卷 / 07期

基金：

英国医学研究理事会;

关键词：

MUTATIONS; VARIANTS; RISK;

D O I：

10.1371/journal.pone.0036123

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C > T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequency of the variant (A419V) to be very rare in our Taiwan PD and controls (?0.6%). Further studies were conducted in two other Chinese populations (Singapore and China), comprising of a total of 3004 subjects including 1517 PD patients and 1487 control subjects. However, our multi-center Chinese study revealed that the frequency of the variant was rare (?0.4%) and was not associated with risk of PD, suggesting that the variant is not a major risk factor for PD among Chinese, at least in our study population.

引用

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