The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication

被引：98
作者：
Smith, CM
Radzio-Andzelm, E
Madhusudan
Akamine, P
Taylor, SS
机构：
[1] Univ Calif San Diego, San Diego Supercomp Ctr, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Chem & Biochem, Howard Hughes Med Inst, La Jolla, CA 92093 USA
来源：
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 1999年 / 71卷 / 3-4期
关键词：
D O I：
10.1016/S0079-6107(98)00059-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The protein kinase catalytic core in essence comprises an extended network of interactions that link distal parts of the molecule to the active site where they facilitate phosphoryl transfer from ATP to protein substrate. This review defines key sequence and structural elements, describes what is currently known about the molecular interactions, and how they are involved in catalysis. (C) 1999 Elsevier Science Ltd. All; rights reserved.
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页码：313 / 341
页数：29
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