Polymorphisms in the ATG16L1 Gene are Associated with Psoriasis Vulgaris

被引:60
作者
Douroudis, Konstantinos [1 ,2 ]
Kingo, Kuelli [2 ,3 ]
Traks, Tanel [1 ,2 ]
Reimann, Ene [1 ,2 ]
Raud, Kristi [1 ,2 ]
Raetsep, Ranno [1 ,2 ]
Moessner, Rotraut [4 ]
Silm, Helgi [2 ,3 ]
Vasar, Eero [1 ,2 ]
Koks, Sulev [1 ,2 ]
机构
[1] Univ Tartu, Dept Physiol, EE-50090 Tartu, Estonia
[2] Univ Tartu, Ctr Translat Med, EE-50090 Tartu, Estonia
[3] Univ Tartu, Dept Dermatol & Venereol, EE-50090 Tartu, Estonia
[4] Univ Gottingen, Dept Dermatol, Gottingen, Germany
关键词
GENOME-WIDE ASSOCIATION; AUTOPHAGY; PROTEIN; DISEASE; MOUSE; LOCI;
D O I
10.2340/00015555-1183
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
引用
收藏
页码:85 / 87
页数:3
相关论文
共 15 条
  • [1] A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    Cadwell, Ken
    Liu, John Y.
    Brown, Sarah L.
    Miyoshi, Hiroyuki
    Loh, Joy
    Lennerz, Jochen K.
    Kishi, Chieko
    Kc, Wumesh
    Carrero, Javier A.
    Hunt, Steven
    Stone, Christian D.
    Brunt, Elizabeth M.
    Xavier, Ramnik J.
    Sleckman, Barry P.
    Li, Ellen
    Mizushima, Noboru
    Stappenbeck, Thaddeus S.
    Virgin, Herbert W.
    [J]. NATURE, 2008, 456 (7219) : 259 - U62
  • [2] The clinical genetics of psoriasis
    Campalani, E
    Barker, JNWN
    [J]. CURRENT GENOMICS, 2005, 6 (01) : 51 - 60
  • [3] NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    Cooney, Rachel
    Baker, John
    Brain, Oliver
    Danis, Benedicte
    Pichulik, Tica
    Allan, Philip
    Ferguson, David J. P.
    Campbell, Barry J.
    Jewell, Derek
    Simmons, Alison
    [J]. NATURE MEDICINE, 2010, 16 (01) : 90 - U128
  • [4] The CD226 Gly307Ser gene polymorphism is associated with severity of psoriasis
    Douroudis, Konstantinos
    Kingo, Kuelli
    Silm, Helgi
    Reimann, Ene
    Traks, Tanel
    Vasar, Eero
    Koks, Sulev
    [J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2010, 58 (02) : 160 - 161
  • [5] A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    Hampe, Jochen
    Franke, Andre
    Rosenstiel, Philip
    Till, Andreas
    Teuber, Markus
    Huse, Klaus
    Albrecht, Mario
    Mayr, Gabriele
    De La Vega, Francisco M.
    Briggs, Jason
    Guenther, Simone
    Prescott, Natalie J.
    Onnie, Clive M.
    Haesler, Robert
    Sipos, Bence
    Foelsch, Ulrich R.
    Lengauer, Thomas
    Platzer, Matthias
    Mathew, Christopher G.
    Krawczak, Michael
    Schreiber, Stefan
    [J]. NATURE GENETICS, 2007, 39 (02) : 207 - 211
  • [6] Autophagy Suppresses Tumorigenesis through Elimination of p62
    Mathew, Robin
    Karp, Cristina M.
    Beaudoin, Brian
    Vuong, Nhan
    Chen, Guanghua
    Chen, Hsin-Yi
    Bray, Kevin
    Reddy, Anupama
    Bhanot, Gyan
    Gelinas, Celine
    DiPaola, Robert S.
    Karantza-Wadsworth, Vassiliki
    White, Eileen
    [J]. CELL, 2009, 137 (06) : 1062 - 1075
  • [7] Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
    Mizushima, N
    Kuma, A
    Kobayashi, Y
    Yamamoto, A
    Matsubae, M
    Takao, T
    Natsume, T
    Ohsumi, Y
    Yoshimori, T
    [J]. JOURNAL OF CELL SCIENCE, 2003, 116 (09) : 1679 - 1688
  • [8] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
    Saitoh, Tatsuya
    Fujita, Naonobu
    Jang, Myoung Ho
    Uematsu, Satoshi
    Yang, Bo-Gie
    Satoh, Takashi
    Omori, Hiroko
    Noda, Takeshi
    Yamamoto, Naoki
    Komatsu, Masaaki
    Tanaka, Keiji
    Kawai, Taro
    Tsujimura, Tohru
    Takeuchi, Osamu
    Yoshimori, Tamotsu
    Akira, Shizuo
    [J]. NATURE, 2008, 456 (7219) : 264 - U68
  • [9] A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
    Strange, Amy
    Capon, Francesca
    Spencer, Chris C. A.
    Knight, Jo
    Weale, Michael E.
    Allen, Michael H.
    Barton, Anne
    Band, Gavin
    Bellenguez, Celine
    Bergboer, Judith G. M.
    Blackwell, Jenefer M.
    Bramon, Elvira
    Bumpstead, Suzannah J.
    Casas, Juan P.
    Cork, Michael J.
    Corvin, Aiden
    Deloukas, Panos
    Dilthey, Alexander
    Duncanson, Audrey
    Edkins, Sarah
    Estivill, Xavier
    Fitzgerald, Oliver
    Freeman, Colin
    Giardina, Emiliano
    Gray, Emma
    Hofer, Angelika
    Hueffmeier, Ulrike
    Hunt, Sarah E.
    Irvine, Alan D.
    Jankowski, Janusz
    Kirby, Brian
    Langford, Cordelia
    Lascorz, Jesus
    Leman, Joyce
    Leslie, Stephen
    Mallbris, Lotus
    Markus, Hugh S.
    Mathew, Christopher G.
    McLean, W. H. Irwin
    McManus, Ross
    Moessner, Rotraut
    Moutsianas, Loukas
    Naluai, Asa T.
    Nestle, Frank O.
    Novelli, Giuseppe
    Onoufriadis, Alexandros
    Palmer, Colin N. A.
    Perricone, Carlo
    Pirinen, Matti
    Plomin, Robert
    [J]. NATURE GENETICS, 2010, 42 (11) : 985 - U106
  • [10] Genome-wide association analysis identifies three psoriasis susceptibility loci
    Stuart, Philip E.
    Nair, Rajan P.
    Ellinghaus, Eva
    Ding, Jun
    Tejasvi, Trilokraj
    Gudjonsson, Johann E.
    Li, Yun
    Weidinger, Stephan
    Eberlein, Bernadette
    Gieger, Christian
    Wichmann, H. Erich
    Kunz, Manfred
    Ike, Robert
    Krueger, Gerald G.
    Bowcock, Anne M.
    Mrowietz, Ulrich
    Lim, Henry W.
    Voorhees, John J.
    Abecasis, Goncalo R.
    Weichenthal, Michael
    Franke, Andre
    Rahman, Proton
    Gladman, Dafna D.
    Elder, James T.
    [J]. NATURE GENETICS, 2010, 42 (11) : 1000 - U125