Physiological roles revealed by ghrelin and ghrelin receptor deficient mice

被引：43
作者：
Albarran-Zeckler, Rosie G. [1 ,2 ]
Sun, Yuxiang [2 ,3 ]
Smith, Roy G. [1 ,2 ]
机构：
[1] Scripps Res Inst Florida, Dept Metab & Aging, Jupiter, FL 33458 USA
[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
[3] Childrens Nutr Res Ctr, Houston, TX 77030 USA
来源：
PEPTIDES | 2011年 / 32卷 / 11期
关键词：
Ghrelin; Ghrelin receptor (GHS-R1a); Ghrein knockout mice; Ghrelin receptor knockout mice; GROWTH-HORMONE SECRETAGOGUE; PARKINSONS-DISEASE; FOOD-INTAKE; ENERGY-BALANCE; KNOCKOUT MICE; RELEASE; PITUITARY; OBESITY; APPETITE; RATS;
D O I：
10.1016/j.peptides.2011.07.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ghrelin is a hormone made in the stomach and known primarily for its growth hormone releasing and orexigenic properties. Nevertheless, ghrelin through its receptor, the GHS-R1a, has been shown to exert many roles including regulation of glucose homeostasis, memory & learning, food addiction and neuroprotection. Furthermore, ghrelin could promote overall health and longevity by acting directly in the immune system and promoting an extended antigen repertoire. The development of mice lacking either ghrelin (ghrelin-/-) or its receptor (ghsr-/-) have provided a valuable tool for determining the relevance of ghrelin and its receptor in these multiple and diverse roles. In this review, we summarize the most important findings and lessons learned from the ghrelin-/- and ghsr-/- mice. Published by Elsevier Inc.
引用
收藏
页码：2229 / 2235
页数：7
相关论文
共 47 条
[1]   Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite [J].
Abizaid, Alfonso ;
Liu, Zhong-Wu ;
Andrews, Zane B. ;
Shanabrough, Marya ;
Borok, Erzsebet ;
Elsworth, John D. ;
Roth, Robert H. ;
Sleeman, Mark W. ;
Picciotto, Marina R. ;
Tschop, Matthias H. ;
Gao, Xiao-Bing ;
Horvath, Tamas L. .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (12) :3229-3239
[2]   Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism [J].
Andrews, Zane B. ;
Erion, Derek ;
Beiler, Rudolph ;
Liu, Zhong-Wu ;
Abizaid, Alfonso ;
Zigman, Jeffrey ;
Elsworth, John D. ;
Savitt, Joseph M. ;
DiMarchi, Richard ;
Tschoep, Matthias ;
Roth, Robert H. ;
Gao, Xiao-Bing ;
Horvath, Tamas L. .
JOURNAL OF NEUROSCIENCE, 2009, 29 (45) :14057-14065
[3]   ON THE INVITRO AND INVIVO ACTIVITY OF A NEW SYNTHETIC HEXAPEPTIDE THAT ACTS ON THE PITUITARY TO SPECIFICALLY RELEASE GROWTH-HORMONE [J].
BOWERS, CY ;
MOMANY, FA ;
REYNOLDS, GA ;
HONG, A .
ENDOCRINOLOGY, 1984, 114 (05) :1537-1545
[4]   Ghrelin increases anxiety-like behavior and memory retention in rats [J].
Carlini, VP ;
Monzón, ME ;
Varas, MM ;
Cragnolini, AB ;
Schiöth, HB ;
Scimonelli, TN ;
de Barioglio, SR .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 299 (05) :739-743
[5]   Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects [J].
Chapman, IM ;
Bach, MA ;
vanCauter, E ;
Farmer, M ;
Krupa, D ;
Taylor, AM ;
Schilling, LM ;
Cole, KY ;
Skiles, EH ;
Pezzoli, SS ;
Hartman, ML ;
Veldhuis, JD ;
Gormley, GJ ;
Thorner, MO .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (12) :4249-4257
[6]  
CHENG K, 1991, ENDOCRINOLOGY, V129, P3337
[7]  
CHENG K, 1989, ENDOCRINOLOGY, V124, P2791
[8]   Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation [J].
Chung, Hyunju ;
Kim, Eunhee ;
Lee, Dae Hee ;
Seo, Sanghee ;
Ju, Sunghee ;
Lee, Dahm ;
Kim, Hocheol ;
Park, Seungjoon .
ENDOCRINOLOGY, 2007, 148 (01) :148-159
[9]  
Clifford S, 2010, ADDICT BIOL
[10]   The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis [J].
Cowley, MA ;
Smith, RG ;
Diano, S ;
Tschöp, M ;
Pronchuk, N ;
Grove, KL ;
Strasburger, CJ ;
Bidlingmaier, M ;
Esterman, M ;
Heiman, ML ;
Garcia-Segura, LM ;
Nillni, EA ;
Mendez, P ;
Low, MJ ;
Sotonyi, P ;
Friedman, JM ;
Liu, HY ;
Pinto, S ;
Colmers, WF ;
Cone, RD ;
Horvath, TL .
NEURON, 2003, 37 (04) :649-661
12345