Nanoplastics: Focus on the role of microRNAs and long non-coding RNAs

被引：16

作者：

Banikazemi, Zarrin ^{[1
,2
]}

Farshadi, Mojgan ^{[3
]}

Rajabi, Ali ^{[2
,4
]}

Homayoonfal, Mina ^{[1
]}

Sharifi, Nasrin ^{[1
]}

Chaleshtori, Reza Sharafati ^{[1
]}

机构：

[1] Kashan Univ Med Sci, Inst Basic Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran

[2] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran

[3] Univ Tehran Med Sci, Res & Dev Ctr, Tehran, Iran

[4] Kashan Univ Med Sci, Sch Med, Kashan, Iran

来源：

CHEMOSPHERE | 2022年 / 308卷

关键词：

Nanoplastics; Toxicity; MicroRNA; Long non-coding RNAs; Food safety; NUCLEAR EXPORT; OXIDATIVE STRESS; TOXICITY; MICROPLASTICS; ELEGANS; MECHANISMS; PARTICLES; IDENTIFY; HEALTH;

D O I：

10.1016/j.chemosphere.2022.136299

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

When plastic objects in our surroundings are degraded, they may produce particles ranging in size from 1 to 100 nm therefore called nanoplastics. The environmental chemicals including nanoplastics may be able to affect biological processes in the nuclear level like altering DNA methylation and regulating microRNAs (miRNAs) as well as long non-coding RNAs (lncRNAs) expression and therefore are implicated in chronic human diseases like neoplasms. The regulatory role of miRNAs and lncRNAs in gene expression is appreciated. In vitro as well as in vivo experiments have shown that environmental elements including nanoplastics are able to dysregulate miRNAs and lncRNAs expression with possible genetic consequences that increase the risk of cancer develop-ment. In the current article, we review the biological effects of miRNAs and lncRNAs alterations following nanoplastics exposure.

引用

页数：7

共 67 条

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