Memantine Attenuates Delayed Vasospasm after Experimental Subarachnoid Hemorrhage via Modulating Endothelial Nitric Oxide Synthase

被引：16
作者：
Huang, Chih-Yuan [1 ,2 ]
Wang, Liang-Chao [1 ,2 ]
Shan, Yan-Shen [1 ,2 ]
Pan, Chia-Hsin [1 ]
Tsai, Kuen-Jer [1 ,3 ]
机构：
[1] Natl Cheng Kung Univ, Coll Med, Inst Clin Med, Tainan 704, Taiwan
[2] Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Surg, Tainan 704, Taiwan
[3] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Ctr Clin Med, Tainan 704, Taiwan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 06期
关键词：
BARRIER PERMEABILITY CHANGES; CEREBRAL VASOSPASM; MELANOCORTINS; ACTIVATION; NO;
D O I：
10.3390/ijms160614171
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Delayed cerebral vasospasm is an important pathological feature of subarachnoid hemorrhage (SAH). The cause of vasospasm is multifactorial. Impairs nitric oxide availability and endothelial nitric oxide synthase (eNOS) dysfunction has been reported to underlie vasospasm. Memantine, a low-affinity uncompetitive N-methyl-d-aspartate (NMDA) blocker has been proven to reduce early brain injury after SAH. This study investigated the effect of memantine on attenuation of vasospasm and restoring eNOS functionality. Male Sprague-Dawley rats weighing 350-450 g were randomly divided into three weight-matched groups, sham surgery, SAH + vehicle, and SAH + memantine groups. The effects of memantine on SAH were evaluated by assessing the severity of vasospasm and the expression of eNOS. Memantine effectively ameliorated cerebral vasospasm by restoring eNOS functionality. Memantine can prevent vasospasm in experimental SAH. Treatment strategies may help combat SAH-induced vasospasm in the future.
引用
收藏
页码：14171 / 14180
页数：10
相关论文
共 35 条
[1]   CORTICAL BLOOD-FLOW AND CEREBRAL PERFUSION-PRESSURE IN A NEW NONCRANIOTOMY MODEL OF SUBARACHNOID HEMORRHAGE IN THE RAT [J].
BEDERSON, JB ;
GERMANO, IM ;
GUARINO, L .
STROKE, 1995, 26 (06) :1086-1091
[2]   Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation [J].
Chen, HSV ;
Wang, YF ;
Rayudu, PV ;
Edgecomb, P ;
Neill, JC ;
Segal, MM ;
Lipton, SA ;
Jensen, FE .
NEUROSCIENCE, 1998, 86 (04) :1121-1132
[3]   ATRIAL-NATRIURETIC-PEPTIDE (ANP) ATTENUATES BRAIN EDEMA ACCOMPANYING EXPERIMENTAL SUBARACHNOID HEMORRHAGE [J].
DOCZI, TP ;
JOO, F ;
BALAS, I .
ACTA NEUROCHIRURGICA, 1995, 132 (1-3) :87-91
[4]   Calcium antagonists for aneurysmal subarachnoid haemorrhage [J].
Dorhout Mees, S. M. ;
Rinkel, G. J. E. ;
Feigin, V. L. ;
Algra, A. ;
van den Bergh, W. M. ;
Vermeulen, M. ;
van Gijn, J. .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2007, (03)
[5]   Cerebral vasospasm after subarachnoid hemorrhage: Putative role of inflammation [J].
Dumont, AS ;
Dumont, RJ ;
Chow, MM ;
Lin, CL ;
Calisaneller, T ;
Ley, KF ;
Kassell, NF ;
Lee, KS .
NEUROSURGERY, 2003, 53 (01) :123-133
[6]   Endothelial nitric oxide synthase in vascular disease -: From marvel to menace [J].
Förstermann, U ;
Münzel, T .
CIRCULATION, 2006, 113 (13) :1708-1714
[7]   EDHF: spreading the influence of the endothelium [J].
Garland, Christopher J. ;
Hiley, C. Robin ;
Dora, Kim A. .
BRITISH JOURNAL OF PHARMACOLOGY, 2011, 164 (03) :839-852
[8]   Protective action of NDP-MSH in experimental subarachnoid hemorrhage [J].
Gatti, Stefano ;
Lonati, Caterina ;
Acerbi, Francesco ;
Sordi, Andrea ;
Leonardi, Patrizia ;
Carlin, Andrea ;
Gaini, Sergio M. ;
Catania, Anna .
EXPERIMENTAL NEUROLOGY, 2012, 234 (01) :230-238
[9]   Time-course of blood-brain barrier permeability changes after experimental subarachnoid haemorrhage [J].
Germanò, A ;
d'Avella, D ;
Imperatore, C ;
Caruso, G ;
Tomasello, F .
ACTA NEUROCHIRURGICA, 2000, 142 (05) :575-581
[10]   NMDA receptor antagonist felbamate reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat [J].
Germano, Antonino ;
Caffo, Mariella ;
Angileri, Filippo Flavio ;
Arcadi, Francesca ;
Newcomb-Fernandez, Jennifer ;
Caruso, Gerardo ;
Meli, Francesco ;
Pineda, Jose A. ;
Lewis, Stephen B. ;
Wang, Kevin K. W. ;
Bramanti, Placido ;
Costa, Chiara ;
Hayes, Ronald L. .
JOURNAL OF NEUROTRAUMA, 2007, 24 (04) :732-744
1234