DNA replication: Partners in the Okazaki two-step

被引：45
作者：
MacNeill, SA [1 ]
机构：
[1] Univ Edinburgh, Inst Cell & Mol Biol, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland
来源：
CURRENT BIOLOGY | 2001年 / 11卷 / 20期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S0960-9822(01)00500-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The correct processing of Okazaki fragments during lagging-strand DNA replication has a vital role in maintaining genome integrity. Recent findings suggest that, in eukaryotes, the processing of Okazaki fragments occurs by a two-step mechanism governed by the single-stranded DNA binding factor RPA.
引用
收藏
页码：R842 / R844
页数：3
相关论文
共 14 条
[1]   Conserved domains in DNA repair proteins and evolution of repair systems [J].
Aravind, L ;
Walker, DR ;
Koonin, EV .
NUCLEIC ACIDS RESEARCH, 1999, 27 (05) :1223-1242
[2]   Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP [J].
Bae, SH ;
Choi, E ;
Lee, KH ;
Park, JS ;
Lee, SH ;
Seo, YS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (41) :26880-26890
[3]   RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes [J].
Bae, SH ;
Bae, KH ;
Kim, JA ;
Seo, YS .
NATURE, 2001, 412 (6845) :456-461
[4]   Characterization of the enzymatic properties of the yeast Dna2 helicase/endonuclease suggests a new model for Okazaki fragment processing [J].
Bae, SH ;
Seo, YS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) :38022-38031
[5]   A YEAST GENE REQUIRED FOR DNA-REPLICATION ENCODES A PROTEIN WITH HOMOLOGY TO DNA HELICASES [J].
BUDD, ME ;
CAMPBELL, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7642-7646
[6]   The nuclease activity of the yeast Dna2 protein, which is related to the RecB-like nucleases, is essential in vivo [J].
Budd, ME ;
Choe, WC ;
Campbell, JL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (22) :16518-16529
[7]   DNA2 ENCODES A DNA HELICASE ESSENTIAL FOR REPLICATION OF EUKARYOTIC CHROMOSOMES [J].
BUDD, ME ;
CHOE, WC ;
CAMPBELL, JL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) :26766-26769
[8]   A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function [J].
Budd, ME ;
Campbell, JL .
MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (04) :2136-2142
[9]   Characterization of Saccharomyces cerevisiae dna2 mutants suggests a role for the helicase late in S phase [J].
Fiorentino, DF ;
Crabtree, GR .
MOLECULAR BIOLOGY OF THE CELL, 1997, 8 (12) :2519-2537
[10]  
Formosa T, 1999, GENETICS, V151, P1459
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