Dynamic Kinetic Resolution of α-Keto Esters via Asymmetric Transfer Hydrogenation

被引：121

作者：

Steward, Kimberly M. ^{[1
]}

Gentry, Emily C. ^{[1
]}

Johnson, Jeffrey S. ^{[1
]}

机构：

[1] Univ N Carolina Chapel Hill, Dept Chem, Chapel Hill, NC 27515 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 17期

关键词：

INTERMOLECULAR STETTER REACTION; ENANTIOSELECTIVE SYNTHESIS; M-TERPHENYLS; KETOAMIDES; COMPLEXES; ALDEHYDES;

D O I：

10.1021/ja3027136

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The dynamic kinetic resolution of beta-aryl alpha-keto esters has been accomplished using a newly designed (arene)RuCl(monosulfonamide) transfer hydrogenation catalyst This dynamic process generates three contiguous stereocenters with remarkable diastereoselectivity through a reduction/lactonization sequence. The resulting enantioenriched, densely functionalized gamma-butyrolactones are of high synthetic utility, as highlighted by several secondary derivatizations.

引用

页码：7329 / 7332

页数：4

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