The Modified Bradykinesia Rating Scale for Parkinson's Disease: Reliability and Comparison with Kinematic Measures

被引：145

作者：

Heldman, Dustin A. ^{[2
]}

Giuffrida, Joseph P. ^{[2
]}

Chen, Robert ^{[3
,4
]}

Payne, Megan ^{[1
]}

Mazzella, Filomena ^{[3
,4
]}

Duker, Andrew P. ^{[1
]}

Sahay, Alok ^{[1
]}

Kim, Sang Jin ^{[3
,4
]}

Revilla, Fredy J. ^{[1
]}

Espay, Alberto J. ^{[1
]}

机构：

[1] Univ Cincinnati, Dept Neurol, UC Neurosci Inst, Gardner Ctr Parkinsons Dis & Movement Disorders, Cincinnati, OH 45267 USA

[2] Cleveland Med Devices Inc, Div Movement Disorders, Cleveland, OH USA

[3] Univ Toronto, Toronto Western Res Inst, Toronto, ON, Canada

[4] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

来源：

MOVEMENT DISORDERS | 2011年 / 26卷 / 10期

关键词：

Parkinson's disease; bradykinesia; Unified Parkinson's Disease Rating Scale; modified bradykinesia rating scale; KinetiSense; QUANTITATIVE ASSESSMENT; QUANTIFICATION; DISABILITY; TREMOR;

D O I：

10.1002/mds.23740

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Bradykinesia encompasses slowness, decreased movement amplitude, and dysrhythmia. Unified Parkinson's Disease Rating Scale-based bradykinesia-related items require that clinicians condense abnormalities in speed, amplitude, fatiguing, hesitations, and arrests into a single score. The objective of this study was to evaluate the reliability of a modified bradykinesia rating scale, which separately assesses speed, amplitude, and rhythm and its correlation with kinematic measures from motion sensors. Fifty patients with Parkinson's disease performed Unified Parkinson's Disease Rating Scale-directed finger tapping, hand grasping, and pronation-supination while wearing motion sensors. Videos were rated blindly and independently by 4 clinicians. The modified bradykinesia rating scale and Unified Parkinson's Disease Rating Scale demonstrated similar inter- and intrarater reliability. Raters placed greater weight on amplitude than on speed or rhythm when assigning a Unified Parkinson's Disease Rating Scale score. Modified bradykinesia rating scale scores for speed, amplitude, and rhythm correlated highly with quantitative kinematic variables. The modified bradykinesia rating scale separately captures bradykinesia components with interrater and intrarater reliability similar to that of the Unified Parkinson's Disease Rating Scale. Kinematic sensors can accurately quantify speed, amplitude, and rhythm to aid in the development and evaluation of novel therapies in Parkinson's disease. (C)2011 Movement Disorder Society

引用

页码：1859 / 1863

页数：5

共 22 条

[1] VALUE AND APPROPRIATE USE OF RATING-SCALES AND APPARATIVE MEASUREMENTS IN QUANTIFICATION OF DISABILITY IN PARKINSONS-DISEASE [J].