1,3-Dihydro-benzo[b][1,4]Diazepin-2-one Derivatives as Potent Non-Competitive Metabotropic Glutamate Receptor 2/3 Antagonists

被引：0

作者：

Woltering, T. J. ^{[1
]}

Wichmann, J. ^{[1
]}

Goetschi, E. ^{[1
]}

Huwyler, J. ^{[1
]}

Knoflach, F. ^{[1
]}

Ballard, T. M. ^{[1
]}

Gatti, S. ^{[1
]}

机构：

[1] F Hoffmann La Roche Ltd, pRED Basel, CH-4070 Basel, Switzerland

来源：

CURRENT NEUROPHARMACOLOGY | 2011年 / 9卷

关键词：

GLUTAMATE-RECEPTOR-2/3; ANTAGONISTS;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

184

引用

收藏

页码：67 / 67

页数：1

相关论文

共 4 条

[1] Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives:: Part 3.: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists [J].

Woltering, Thomas J. ;

Wichmann, Juergen ;

Goetschi, Erwin ;

Adam, Geo ;

Kew, James N. C. ;

Knoflach, Frederic ;

Ballard, Theresa M. ;

Huwyler, Joerg ;

Mutel, Vincent ;

Gatti, Silvia .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (08) :2725-2729

[2] Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives:: Part 2.: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists [J].

Woltering, Thomas J. ;

Adam, Geo ;

Wichmann, Juergen ;

Goetschi, Erwin ;

Kew, James N. C. ;

Knoflach, Frederic ;

Mutel, Vincent ;

Gatti, Silvia .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (03) :1091-1095

[3] Synthesis and characterization of 8-ethynyl-1,3-dihydrobenzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1 [J].

Woltering, Thomas J. ;

Adam, Geo ;

Alanine, Alexander ;

Wichmann, Juergen ;

Knoflach, Frederic ;

Mutel, Vincent ;

Gatti, Silvia .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (24) :6811-6815

[4] Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists [J].

Woltering, Thomas J. ;

Wichmann, Juergen ;

Goetschi, Erwin ;

Knoflach, Frederic ;

Ballard, Theresa M. ;

Huwyler, Joerg ;

Gatti, Silvia .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (23) :6969-6974