A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity

被引：46
作者：
Kitajima, Mariko
Misawa, Kaori
Kogure, Noriyuki
Said, Ikram M.
Horie, Syunji
Hatori, Yoshio
Murayama, Toshihiko
Takayama, Hiromitsu
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan
[2] Univ Kebangsaan Malaysia, Fac Sci & Technol, Bangi 43600, Selangor, Malaysia
[3] Josai Int Univ, Fac Pharmaceut Sci, Pharmacol Lab, Chiba 2838555, Japan
来源：
JOURNAL OF NATURAL MEDICINES | 2006年 / 60卷 / 01期
关键词：
Mitragyna speciosa; indole alkaloid; 7-hydroxyspeciociliatine; structure determination; opioid agonist; mu-opioid receptor;
D O I：
10.1007/s11418-005-0001-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new indole alkaloid, 7-hydroxyspeciociliatine (1), was isolated from the fruits of Malaysian Mitragyna speciosa Korth., together with 11 known indole and oxindole alkaloids (3-13). The structure of the new compound was determined by spectroscopic analysis and chemical conversion. The opioid agonistic activity of the new alkaloid was investigated in guinea-pig ileum experiments. The compound was found to have a weak stimulatory effect of mu-opioid receptors.
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页码：28 / 35
页数：8
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