Randomized Controlled Trial of Osmotic-Release Methylphenidate With Cognitive-Behavioral Therapy in Adolescents With Attention-Deficit/Hyperactivity Disorder and Substance Use Disorders

被引：71

作者：

Riggs, Paula D. ^{[1
]}

Winhusen, Theresa ^{[2
]}

Davies, Robert D. ^{[1
]}

Leimberger, Jeffrey D.

Mikulich-Gilbertson, Susan ^{[1
]}

Klein, Constance ^{[1
]}

Macdonald, Marilyn ^{[1
]}

Lohman, Michelle ^{[1
]}

Bailey, Genie L. ^{[3
]}

Haynes, Louise ^{[4
]}

Jaffee, William B. ^{[5
]}

Haminton, Nancy

Hodgkins, Candace

Whitmore, Elizabeth ^{[1
]}

Trello-Rishel, Kathlene

Tamm, Leanne

Acosta, Michelle C.

Royer-Malvestuto, Charlotte ^{[6
]}

Subramaniam, Geetha ^{[7
,8
]}

Fishman, Marc ^{[7
]}

Holmes, Beverly W.

Kaye, Mary Elyse ^{[9
]}

Vargo, Mark A.

Woody, George E. ^{[6
]}

Nunes, Edward V. ^{[10
,11
]}

Liu, David ^{[12
]}

机构：

[1] Univ Colorado Denver, Aurora, CO 80045 USA

[2] Univ Cincinnati, Cincinnati, OH 45221 USA

[3] Brown Univ, Providence, RI 02912 USA

[4] Med Univ S Carolina, Charleston, SC USA

[5] Harvard Univ, Cambridge, MA 02138 USA

[6] Univ Penn, Philadelphia, PA 19104 USA

[7] Johns Hopkins Univ, Baltimore, MD 21218 USA

[8] NIDA, Div Clin Neurosci & Behav Res, NIH, Bethesda, MD USA

[9] Univ Pittsburgh, Pittsburgh, PA 15260 USA

[10] Columbia Univ, New York, NY 10027 USA

[11] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[12] NIDA, Ctr Clin Trials Network, NIH, Bethesda, MD USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY | 2011年 / 50卷 / 09期

关键词：

osmotic-release methylphenidate; randomized controlled trial; ADHD; substance use disorders; ADULT ADHD; YOUNG-ADULTS; ABUSE; RELIABILITY; ATOMOXETINE; PREVALENCE; VALIDITY; SAMPLE; MISUSE;

D O I：

10.1016/j.jaac.2011.06.010

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

To evaluate the efficacy and safety of osmotic-release methylphenidate (OROSMPH) compared with placebo for attention-deficit/hyperactivity disorder (ADHD), and the impact on substance treatment outcomes in adolescents concurrently receiving cognitive-behavioral therapy (CBT) for substance use disorders (SUD). Method: This was a 16-week, randomized, controlled, multi-site trial of OROS-MPH + CBT versus placebo + CBT in 303 adolescents (aged 13 through 18 years) meeting DSM-IV diagnostic criteria for ADHD and SUD. Primary outcome measures included the following: for ADHD, clinician-administered ADHD Rating Scale (ADHD-RS), adolescent informant; for substance use, adolescent-reported days of use in the past 28 days. Secondary outcome measures included parent ADHD-RS and weekly urine drug screens (UDS). Results: There were no group differences on reduction in ADHD-RS scores (OROS-MPH: -19.2, 95% confidence interval [CI], -17.1 to -21.2; placebo, -21.2, 95% CI, -19.1 to -23.2) or reduction in days of substance use (OROS-MPH: -5.7 days, 95% Cl, 4.0-7.4; placebo: -5.2 days, 95% CI, 3.5-7.0). Some secondary outcomes favored OROS-MPH, including lower parent ADHD-RS scores at 8 (mean difference = 4.4, 95% CI, 0.8-7.9) and 16 weeks (mean difference =6.9; 95% CI, 2.9-10.9) and more negative UDS in OROS-MPH (mean = 3.8) compared with placebo (mean = 2.8; p =.04). Conclusions: OROS-MPH did not show greater efficacy than placebo for ADHD or on reduction in substance use in adolescents concurrently receiving individual CBT for co-occurring SUD. However, OROS-MPH was relatively well tolerated and was associated with modestly greater clinical improvement on some secondary ADHD and substance outcome measures. Clinical Trial Registration Information Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents with Substance Use Disorders (SUD); http://www.clinicaltrials.gov; NCT00264797. J. Am. Acad. Child Adolesc. Psychiatry, 2011;50(9):903-914.

引用

页码：903 / 914

页数：12

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