DEVELOPMENT OF NEW SULFUR-CONTAINING CONJUGATED COMPOUNDS AS ANTI-HCV AGENTS

被引：7
作者：
Hwu, Jih Ru [1 ,2 ]
Lin, Shu-Yu [1 ]
Tsay, Shwu-Chen [1 ]
Singha, Raghunath [1 ]
Pal, Benoy K. [1 ]
Leyssen, Pieter [3 ]
Neyts, Johan [3 ]
机构：
[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan
[2] Natl Cent Univ, Dept Chem, Jhongli, Taiwan
[3] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2011年 / 186卷 / 05期
关键词：
Coumarin; guanosine; heterocycles; methylenethio linker; DERIVATIVES; INHIBITORS; POTENT; REPLICATION; GUANOSINE;
D O I：
10.1080/10426507.2010.520284
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Various conjugated compounds containing a coumarin moiety and a heterocyclic nucleus were synthesized. Their activity against hepatitis C virus was tested on subgenomic replicon replication in Huh 5-2 cells. Some heterobicycle-coumarin conjugates with the -S-CH2-linker were found to possess appealing antiviral activities. The sulfur atom in these conjugated compounds was found to be an essential element to their antiviral activity.
引用
收藏
页码：1144 / 1152
页数：9
相关论文
共 20 条
  • [1] Synthesis and anti-Hantaan virus activity of N1-3-fluorophenyl-inosine
    Chung, Dong-Hoon
    Strouse, J. Jacob
    Sun, Yanjie
    Arterburn, Jeffrey B.
    Parker, William B.
    Jonsson, Colleen B.
    [J]. ANTIVIRAL RESEARCH, 2009, 83 (01) : 80 - 85
  • [2] Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization
    Goulet, Sylvie
    Poupart, Marc-Andre
    Gillard, James
    Poirier, Martin
    Kukolj, George
    Beaulieu, Pierre L.
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (01) : 196 - 200
  • [3] Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: Structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109
    Hirashima, Shintaro
    Suzuki, Takayoshi
    Ishida, Tomio
    Noji, Satoru
    Yata, Shinji
    Ando, Izuru
    Komatsu, Masakazu
    Ikeda, Satoru
    Hashimoto, Hiromasa
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (15) : 4721 - 4736
  • [4] Synthesis of new benzimidazole-coumarin conjugates as anti-hepatitis C virus agents
    Hwu, Jih Ru
    Singha, Raghunath
    Hong, Shih Ching
    Chang, Yung Hsiung
    Das, Asish R.
    Vliegen, Inge
    De Clercq, Erik
    Neyts, Johan
    [J]. ANTIVIRAL RESEARCH, 2008, 77 (02) : 157 - 162
  • [5] GENOMICS Hepatitis C virus gets personal
    Iadonato, Shawn P.
    Katze, Michael G.
    [J]. NATURE, 2009, 461 (7262) : 357 - 358
  • [6] Kaye PT, 2003, SYNTHESIS-STUTTGART, P531
  • [7] KIRKIACHARIAN BS, 1986, SYNTHESIS-STUTTGART, P383
  • [8] 8-SUBSTITUTED GUANOSINE AND 2'-DEOXYGUANOSINE DERIVATIVES AS POTENTIAL INDUCERS OF THE DIFFERENTIATION OF FRIEND-ERYTHROLEUKEMIA CELLS
    LIN, TS
    CHENG, JC
    ISHIGURO, K
    SARTORELLI, AC
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (09) : 1194 - 1198
  • [9] Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    Lohmann, V
    Körner, F
    Koch, JO
    Herian, U
    Theilmann, L
    Bartenschlager, R
    [J]. SCIENCE, 1999, 285 (5424) : 110 - 113
  • [10] Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
    McCauley, John A.
    McIntyre, Charles J.
    Rudd, Michael T.
    Nguyen, Kevin T.
    Romano, Joseph J.
    Butcher, John W.
    Gilbert, Kevin F.
    Bush, Kimberly J.
    Holloway, M. Katharine
    Swestock, John
    Wan, Bang-Lin
    Carroll, Steven S.
    DiMuzio, Jillian M.
    Graham, Donald J.
    Ludmerer, Steven W.
    Mao, Shi-Shan
    Stahlhut, Mark W.
    Fandozzi, Christine M.
    Trainor, Nicole
    Olsen, David B.
    Vacca, Joseph P.
    Liverton, Nigel J.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (06) : 2443 - 2463
12