Copy number variations identified in thyroid FNA specimens are associated with Hurthle cell cytomorphology

被引:8
作者
Abi-Raad, Rita [1 ]
Prasad, Manju L. [1 ]
Adeniran, Adebowale J. [1 ]
Cai, Guoping [1 ]
机构
[1] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA
关键词
copy number variations; fine-needle aspiration; Hurthle cell features; Hurthle cell neoplasm; thyroid; FINE-NEEDLE-ASPIRATION; CHROMOSOMAL-ABERRATIONS; CANCER-DIAGNOSIS; LESIONS; CARCINOMA; NODULES; BENIGN; TUMORS; PERFORMANCE; CLASSIFIER;
D O I
10.1002/cncy.22569
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background The fine-needle aspiration (FNA) diagnosis of thyroid Hurthle cell neoplasms (HCNs) remains challenging. This study explored a possible association of copy number variations (CNVs) with Hurthle cell lesions of the thyroid. Methods Thyroid FNA cases that were diagnosed as follicular lesion of undetermined significance (FLUS) or follicular neoplasm (FN)/HCN for which the ThyroSeq version 3 genomic classifier test was performed were retrieved. Results A total of 324 thyroid FNA cases (228 FLUS cases, 46 HCN cases, and 50 FN cases) were included in the study. FLUS cases were further classified as Hurthle cell type (follicular lesion of undetermined significance-Hurthle cell type [FLUS-HCT]; 20 cases) or non-Hurthle cell type (follicular lesion of undetermined significance-non-Hurthle cell type [FLUS-NHCT]; 208 cases). HCN and FLUS-HCT cases showed a higher prevalence of CNVs (23 of 66 [35%]) in comparison with those classified as FN or FLUS-NHCT (14 of 258 [5%]; P < .001). A total of 105 patients had histopathologic follow-up. Cases with CNVs were more likely to be neoplastic (18 of 26 [69%]) and associated with Hurthle cell changes (14 of 26 [54%]) in comparison with cases without any molecular alterations (neoplastic, 8 of 24 [33%]; Hurthle cell changes, 2 of 24 [8%]; P < .05). In HCN/FLUS-HCT cases with CNVs (n = 14), Hurthle cell changes (13 of 14 [93%]) and neoplasms (9 of 14 [64%]) were more likely to be seen on surgical follow-up in comparison with the 17 cases without CNVs (Hurthle cell changes, 6 of 17 [35%]; neoplastic, 3 of 17 [18%]; P < .05). Conclusions CNVs identified in thyroid FNA cases are associated with Hurthle cell morphology and are suggestive of a neoplasm with Hurthle cell features in thyroid FNAs classified as FLUS-HCT/HCN. This finding may be helpful in triaging patients who would benefit from surgical management.
引用
收藏
页码:415 / 422
页数:8
相关论文
共 36 条
  • [21] DNA Copy Number Variations Characterize Benign and Malignant Thyroid Tumors
    Liu, Yan
    Cope, Leslie
    Sun, Wenyue
    Wang, Yongchun
    Prasad, Nijaguna
    Sangenario, Lauren
    Talbot, Kristen
    Somervell, Helina
    Westra, William
    Bishop, Justin
    Califano, Joseph
    Zeiger, Martha
    Umbricht, Christopher
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (03) : E558 - E566
  • [22] Macé A, 2018, METHODS MOL BIOL, V1793, P231, DOI 10.1007/978-1-4939-7868-7_14
  • [23] Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology -: A study with emphasis on Hurthle cell tumors
    Máximo, V
    Soares, P
    Lima, J
    Cameselle-Teijeiro, J
    Sobrinho-Simoes, M
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2002, 160 (05) : 1857 - 1865
  • [24] Impact of the Multi-Gene ThyroSeq Next-Generation Sequencing Assay on Cancer Diagnosis in Thyroid Nodules with Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Cytology
    Nikiforov, Yuri E.
    Carty, Sally E.
    Chiosea, Simon I.
    Coyne, Christopher
    Duvvuri, Umamaheswar
    Ferris, Robert L.
    Gooding, William E.
    LeBeau, Shane O.
    Ohori, N. Paul
    Seethala, Raja R.
    Tublin, Mitchell E.
    Yip, Linwah
    Nikiforova, Marina N.
    [J]. THYROID, 2015, 25 (11) : 1217 - 1223
  • [25] Analytical Performance of the ThyroSeq v3 Genomic Classifier for Cancer Diagnosis in Thyroid Nodules
    Nikiforova, Marina N.
    Mercurio, Stephanie
    Wald, Abigail I.
    de Moura, Michelle Barbi
    Callenberg, Keith
    Santana-Santos, Lucas
    Gooding, William E.
    Yip, Linwah
    Ferris, Robert L.
    Nikiforov, Yuri E.
    [J]. CANCER, 2018, 124 (08) : 1682 - 1690
  • [26] Nikiforova MN., 2020, J ENDOCR SOC, V4, pOR21
  • [27] Ohori N Paul, 2020, J Am Soc Cytopathol, V9, P213, DOI 10.1016/j.jasc.2020.03.004
  • [28] Hurthle cell carcinoma is a better gold standard than Hurthle cell neoplasm for fine-needle aspiration of the thyroid - Defining more consistent and specific cytologic criteria
    Renshaw, AA
    [J]. CANCER CYTOPATHOLOGY, 2002, 96 (05) : 261 - 266
  • [29] Rogue L, 1999, LAB INVEST, V79, P369
  • [30] Hurthle cell lesions on thyroid fine needle aspiration cytology: Molecular and histologic correlation
    Schatz-Siemers, Nina
    Brandler, Tamar C.
    Oweity, Thaira
    Sun, Wei
    Hernandez, Andrea
    Levine, Pascale
    [J]. DIAGNOSTIC CYTOPATHOLOGY, 2019, 47 (10) : 977 - 985