1,3,4-Thiadiazole Scaffold: Anti-Microbial Agents

被引：16

作者：

Anthwal, Tulika ^{[1
]}

Singh, HariOm ^{[2
]}

Nain, Sumitra ^{[1
]}

机构：

[1] Banasthali Vidyapith, Dept Pharm, Banasthali 304022, Rajasthan, India

[2] Natl AIDS Res Inst, Dept Mol Biol, Pune 411026, Maharashtra, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2022年 / 55卷 / 12期

关键词：

anti-microbial; antihypertensive; anti-inflammatory; structure; activity relationship; pharmacophore pattern; 1; 3; 4-thiadiazole; THIADIAZOLE DERIVATIVES; ANTICONVULSANT; BEARING; 1,2,4-TRIAZOLE;

D O I：

10.1007/s11094-022-02580-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1,3,4-Thiadiazole moiety has various biological activities including anticancer, antidiabetic, antihypertensive, anti-inflammatory, antiviral, and anti-microbial. Some drugs with thiadiazole scaffold, e.g., sulfamethoxazole, acetazolamide, and butazolamide produce diverse biological action. From the in-dept literature review, some structural modifications in the 1,3,4-thiadiazole ring have resulted in highly effective and less toxic compounds and have good prospects as anti-microbial agents. The present review considers some structural modifications of thiadiazole scaffold that can be beneficial for anti-microbial activity.

引用

页码：1345 / 1358

页数：14

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