Colorectal Neuroendocrine Neoplasms: Areas of Unmet Need

被引：27

作者：

Ramage, John K. ^{[1
,47
]}

Valle, Juan W. ^{[2
,58
]}

van Dijkum, Els J. M. Nieveen ^{[3
]}

Sundin, Anders ^{[4
,5
,53
]}

Pascher, Andreas ^{[6
,7
]}

Couvelard, Anne ^{[8
,9
,20
]}

Kloeppel, Guenter ^{[10
,33
]}

Bartsch, Detlef ^{[11
]}

Arnold, Rudolf ^{[12
]}

Baudin, Eric ^{[13
]}

Bodei, Lisa ^{[14
]}

Borbath, Iva ^{[15
]}

Capdevila, Jaume ^{[16
]}

Caplin, Matyn ^{[17
]}

Chen, Jie ^{[18
]}

Costa, Frederico ^{[19
]}

Couvelard, Anne ^{[8
,9
,20
]}

Cwikla, Jaroslaw B. ^{[21
]}

Davies, Philippa

de Herder, Wouter W. ^{[22
]}

Falconi, Massimo ^{[23
]}

Falkerby, Jenny ^{[24
]}

Fazio, Nicola ^{[25
]}

Ferone, Diego ^{[26
]}

Frilling, Andrea ^{[27
]}

Garcia-Carbonero, Rocio ^{[28
]}

Glasberg, Simona

Gorbunova, Vera

Grossman, Ashley ^{[29
]}

Hoersch, Dieter ^{[30
]}

Jensen, Robert ^{[31
]}

Kaltsas, Gregory ^{[32
]}

Kloeppel, Guenter ^{[10
,33
]}

Kingge, Ulrich Peter ^{[34
]}

Kos-Kudla, Beata ^{[35
]}

Krejs, Guenter J. ^{[36
]}

Krenning, Eric ^{[37
]}

Kulke, Matthew ^{[38
]}

Lamberts, Steven W. J.

Van Dijkum, Nieveen Els J. M. ^{[39
]}

O'Connor, Juan Manuel ^{[40
]}

O'Toole, Dermot ^{[41
,42
]}

Pape, Ulrich-Frank ^{[43
]}

Partelli, Stefano ^{[44
]}

Pavel, Marianne Ellen ^{[45
]}

Peeters, Marc ^{[46
]}

Ramage, John K. ^{[1
,47
]}

Reed, Nicholas Simon ^{[48
]}

Rindi, Guido ^{[49
]}

Rinke, Anja ^{[50
]}

机构：

[1] Kings Coll Hosp London, Hampshire Hosp NHS Trust, ENETS Ctr Excellence, Dept Gastroenterol, Basingstoke, Hants, England

[2] Univ Manchester, Christie ENETS Ctr Excellence, Dept Med Oncol, Manchester, Lancs, England

[3] Dept Surg, Amsterdam, Netherlands

[4] Uppsala Univ, Inst Surg Sci, Dept Radiol, Uppsala, Sweden

[5] Uppsala Univ Hopsital, ENETS Ctr excellence, Uppsala, Sweden

[6] Charite Univ Med Berlin, Dept Surg, Berlin, Germany

[7] Univ Munster, Dept Visceral & Transplant Surg, Munster, Germany

[8] Hop Xavier Bichat, AP HP, Dept Pathol, Paris, France

[9] Univ Paris Diderot, Paris, France

[10] Tech Univ Munich, Dept Pathol, Munich, Germany

[11] UKGM GmbH, Marburg, Germany

[12] Univ Hosp Marburg, Marburg, Germany

[13] Inst Gustave Roussy, Villejuif, France

[14] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[15] Clin Univ St Luc, St Luc, Belgium

[16] Vall dHebron Univ Hosp, VHIO, Barcelona, Spain

[17] Royal Free Hosp, Dept Med, London, England

[18] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[19] Care Of Frederico Costa, Regina Lima, Oncoclin Med Associados SS Ltda, Bebedouro, Brazil

[20] Hop Bichat Claude Bernard, Serv Pathol, Paris, France

[21] Univ Warmia & Mazury, Fac Med Sci, Dept Radiol, Olsztyn, Poland

[22] Erasmus MC, Dept Internal Med, Sect Endocrinol, Rotterdam, Netherlands

[23] Univ Vita & Salute, Dept Surg, Milan, Italy

[24] Dept Endocrine Oncol, Uppsala, Sweden

[25] European Inst Oncol, Milan, Italy

[26] Univ Genoa, Genoa, Italy

[27] Imperial Coll London, Hammersmith Hosp, Dept Surg & Canc, London, England

[28] Hosp Univ Doce Octube, Madrid, Spain

[29] Royal Free London, London, England

[30] Zent Klin Bad Berka GmbH, CA Gastroenterol, Bad Berka, Germany

[31] NIH, Bldg 10, Bethesda, MD 20892 USA

[32] Natl Univ Athens, Dept Pathophysiol, Endocrine Unit, Athens, Greece

[33] Tech Univ Munich, Dept Pathol, Consultat Ctr Pancreat & Endocrine Tumors, Munich, Germany

[34] Rigshosp, Dept Surg C2122, Copenhagen, Denmark

[35] Med Univ Silesia, Dept Endocrinol & Neuroendocrine Tumors, Katowice, Poland

[36] Univ Klin Innere Med, Vienna, Austria

[37] Erasmus MC, Rotterdam, Netherlands

[38] Dana Farber Canc Inst, Boston, MA 02115 USA

[39] Amsterdam Working Hosp, Amsterdam, Netherlands

[40] Inst Fleming, Buenos Aires, DF, Argentina

[41] St Jamess & St Vincents Univ Hosp, Dublin, Ireland

[42] Trinity Coll Dublin, Dublin, Ireland

[43] Charite Campus Mitte, Berlin, Germany

[44] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Pancreas Translat & Clin Res Ctr, Pancreat Surg Unit, Milan, Italy

[45] Univ Klinikum Erlangen, Erlangen, Germany

[46] Antwerp Univ Hosp, Dept Oncol, Edegem, Belgium

[47] Hampshire Hosp NHS Trust, Basingstoke, Hants, England

[48] Gartnavel Royal Hosp, Beatson Oncol Ctr, Glasgow, Lanark, Scotland

[49] Policlin Univ A Gemelli, Rome, Italy

[50] Uniklinikum Giessen & Marburg, Marburg, Germany

来源：

NEUROENDOCRINOLOGY | 2019年 / 108卷 / 01期

关键词：

Carcinoid tumours; Gastroenteropancreatic neuroendocrine tumours; Neuroendocrine tumour; Somatostatin receptor; ENETS CONSENSUS GUIDELINES; MIXED ADENONEUROENDOCRINE CARCINOMAS; TUMORS; RESECTION; SURVIVAL; COLON; MANAGEMENT; RECTUM; G3; DIFFERENTIATION;

D O I：

10.1159/000493767

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The subject of colorectal neuroendocrine neoplasms (NENs), subdivided into well-differentiated NENs, termed neuroendocrine tumours (NETs; grade (G) 1 and 2), and poorly differentiated NENs, termed neuroendocrine carcinomas (NECs; G3) according to the 2010 World Health Organisation (WHO) classification, has arguably not had as much attention or study as NENs occurring in other sites. Colorectal NETs and NECs are however easier to study than many others since they are usually not difficult to remove and are increasingly detected because of intensified colorectal cancer screening and surveillance programmes. Colorectal NETs and NECs show site-specific heterogeneity with variable behaviour and different therapeutic options; these various aspects provide unique challenges. Because of bowel cancer screening programmes, colorectal NENs, like conventional adenocarcinomas, may be diagnosed at a stage that is associated with improved survival. In this article we intend to describe and define areas of unmet needs relating to the epidemiology, classification, pathology, diagnosis and therapy of colorectal NETs (including NETs G3), colorectal NECs, and finally, mixed adeno-neuroendocrine carcinomas (MANECs) by reviewing and discussing the relevant literature.

引用

页码：45 / 53

页数：9

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