Left Ventricular Ejection Time Measured by Echocardiography Differentiates Neurobehavioral Resilience and Vulnerability to Sleep Loss and Stress

被引:8
作者
Yamazaki, Erika M. [1 ]
Rosendahl-Garcia, Kathleen M. [2 ]
Casale, Courtney E. [1 ]
MacMullen, Laura E. [3 ]
Ecker, Adrian J. [3 ]
Kirkpatrick, James N. [4 ]
Goel, Namni [1 ]
机构
[1] Rush Univ, Med Ctr, Dept Psychiat & Behav Sci, Biol Rhythms Res Lab, Chicago, IL 60612 USA
[2] Siemens Healthineers Inc, Mountain View, CA USA
[3] Univ Penn, Perelman Sch Med, Dept Psychiat, Div Sleep & Chronobiol, Philadelphia, PA 19104 USA
[4] Univ Washington, Dept Med, Div Cardiol, Seattle, WA 98195 USA
基金
美国国家卫生研究院; 美国国家航空航天局;
关键词
hemodynamics; sleep deprivation; psychological stress; neurobehavioral performance; Karolinska Sleepiness Scale; biomarkers; echocardiography; Psychomotor Vigilance Test; BLOOD-PRESSURE; CARDIAC-OUTPUT; FUNCTIONAL CONNECTIVITY; INDIVIDUAL-DIFFERENCES; DEPRIVATION; PERFORMANCE; CONSEQUENCES; VARIABILITY; DURATION; RESTRICTION;
D O I
10.3389/fphys.2021.795321
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
There are substantial individual differences (resilience and vulnerability) in performance resulting from sleep loss and psychosocial stress, but predictive potential biomarkers remain elusive. Similarly, marked changes in the cardiovascular system from sleep loss and stress include an increased risk for cardiovascular disease. It remains unknown whether key hemodynamic markers, including left ventricular ejection time (LVET), stroke volume (SV), heart rate (HR), cardiac index (CI), blood pressure (BP), and systemic vascular resistance index (SVRI), differ in resilient vs. vulnerable individuals and predict differential performance resilience with sleep loss and stress. We investigated for the first time whether the combination of total sleep deprivation (TSD) and psychological stress affected a comprehensive set of hemodynamic measures in healthy adults, and whether these measures differentiated neurobehavioral performance in resilient and vulnerable individuals. Thirty-two healthy adults (ages 27-53; 14 females) participated in a 5-day experiment in the Human Exploration Research Analog (HERA), a high-fidelity National Aeronautics and Space Administration (NASA) space analog isolation facility, consisting of two baseline nights, 39 h TSD, and two recovery nights. A modified Trier Social Stress Test induced psychological stress during TSD. Cardiovascular measure collection [SV, HR, CI, LVET, BP, and SVRI] and neurobehavioral performance testing (including a behavioral attention task and a rating of subjective sleepiness) occurred at six and 11 timepoints, respectively. Individuals with longer pre-study LVET (determined by a median split on pre-study LVET) tended to have poorer performance during TSD and stress. Resilient and vulnerable groups (determined by a median split on average TSD performance) showed significantly different profiles of SV, HR, CI, and LVET. Importantly, LVET at pre-study, but not other hemodynamic measures, reliably differentiated neurobehavioral performance during TSD and stress, and therefore may be a biomarker. Future studies should investigate whether the non-invasive marker, LVET, determines risk for adverse health outcomes.
引用
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页数:17
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