Correlation of GDF5 and connexin 43 mRNA expression during embryonic development

被引：22

作者：

Coleman, CM

Loredo, GA

Lo, CW

Tuan, RS

机构：

[1] NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[2] NHLBI, Dev Biol Lab, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[3] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

[4] Thomas Jefferson Univ, Dept Orthopaed Surg, Philadelphia, PA 19107 USA

来源：

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY | 2003年 / 275A卷 / 02期

关键词：

growth/differentiation factor 5; connexin; 43; chondrogenesis; heart development; spine development; tendon development;

D O I：

10.1002/ar.a.10125

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Growth/differentiation factor 5 (GDF5) regulates connexin expression and enhances embryonic chondrogenesis in a gap junction-dependent manner, suggesting that GDF5 action on developmental skeletogenesis is coordinated with gap junction activities. The results shown here demonstrate concordance between the mRNA expression profiles of GDF5 and the gap junction gene, Cx43, in the mouse embryonic limb, spine, and heart, consistent with coordinated functions for these gene products during developmental organogenesis. (C) 2003 Wiley-Liss, Inc.

引用

页码：1117 / 1121

页数：5

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