Idiopathic short stature: Definition, epidemiology, and diagnostic evaluation

被引：166

作者：

Wit, J. M. ^{[1
]}

Clayton, P. E. ^{[2
]}

Rogol, A. D. ^{[3
]}

Savage, M. O. ^{[4
]}

Saenger, P. H. ^{[5
]}

Cohen, P. ^{[6
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Pediat, Leiden, Netherlands

[2] Royal Manchester Childrens Hosp, Dept Endocrinol, Manchester M27 1HA, Lancs, England

[3] Univ Virginia, Dept Pediat, Charlottesville, VA 22911 USA

[4] Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, Ctr Endocrinol, London, England

[5] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA

[6] Univ Calif Los Angeles, Mattel Childrens Hosp, Dept Pediat Endocrinol, Los Angeles, CA 90095 USA

来源：

GROWTH HORMONE & IGF RESEARCH | 2008年 / 18卷 / 02期

关键词：

growth; short stature; idiopathic short stature; diagnosis; growth hormone deficiency;

D O I：

10.1016/j.ghir.2007.11.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Idiopathic short stature is a condition in which the height of the individual is more than 2 SD below the corresponding mean height for a given age, sex and population, in whom no identifiable disorder is present. It can be subcategorized into familial and non-familial ISS, and according to pubertal delay. It should be differentiated from dysmorphic syndromes, skeletal dysplasias, short stature secondary to a small birth size (small for gestational age, SGA), and systemic and endocrine diseases. ISS is the diagnostic group that remains after excluding known conditions in short children. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：89 / 110

页数：22

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