5-HT6 receptor antagonist SB-271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex

被引：134

作者：

Lacroix, LP ^{[1
]}

Dawson, LA ^{[1
]}

Hagan, JJ ^{[1
]}

Heidbreder, CA ^{[1
]}

机构：

[1] GlaxoSmithKline, Ctr Excellence Drug Discovery Psychiat, Dept Biol, I-37135 Verona, Italy

来源：

SYNAPSE | 2004年 / 51卷 / 02期

关键词：

5-HT6; receptor; dopamine; medial prefrontal cortex; microdialysis; norepinephrine; SB-271046; serotonin;

D O I：

10.1002/syn.10288

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study investigated the neurochemical effects of the selective 5-HT6 receptor antagonist SB-271046 in the rat medial prefrontal cortex (mPFC). The effect of SB-271046 on extracellular levels of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in the mPFC was examined using in vivo microdialysis in the freely moving rat. SB-271046 (10 mg/kg, p.o.) produced a significant increase in extracellular levels of both DA and NE without altering 5-HT neurotransmission. These results further support the rationale for the use of 5-HT6 receptor antagonists in the treatment of cognitive dysfunction associated with psychiatric diseases. (C) 2003 Wiley-Liss, Inc.

引用

页码：158 / 164

页数：7

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