Brown adipose tissue and its therapeutic application

被引：8

作者：

Yuan, Xiaoxue ^{[1
,2
]}

Dong, Meng ^{[1
,2
]}

Lee, Hyuek Jong ^{[1
]}

Jin, Wanzhu ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

SCIENCE BULLETIN | 2016年 / 61卷 / 19期

关键词：

Brown adipose tissue; Lipid metabolism; Therapeutic application; ENERGY-EXPENDITURE; COLD-EXPOSURE; GLUCOSE-HOMEOSTASIS; INSULIN SENSITIVITY; BEIGE ADIPOCYTES; WHITE; FAT; THERMOGENESIS; FGF21; METABOLISM;

D O I：

10.1007/s11434-016-1051-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In addition to white adipose tissue (WAT) that stores energy, human and small mammals also have brown adipose tissue (BAT) that dissipates chemical energy for thermogenesis. BAT contains multilocular lipid droplets and much higher numbers of mitochondria than WAT. The mitochondria in BAT uncouple large amounts of fuel oxidation from ATP for heat generation. Accumulating evidences have demonstrated that increased activity and/or amount of BAT can reverse obesity and improve insulin resistance, which highlights that BAT plays an important role in energy metabolism. In this review, we summarized recent findings that shows advantageous effects of BAT activation in metabolic diseases. In addition, we presented the function and role of brown and beige fat cells and regulatory factors for them. Finally, we discussed the potential application of brown adipocytes-based therapy and pharmacological intervention to increase BAT activity for the treatment of obesity and related diseases including insulin resistance, cardiovascular diseases and type 2 diabetes.

引用

页码：1498 / 1503

页数：6

共 90 条

[41] Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice [J].

Liu, Xiaomeng ;

Wang, Siping ;

You, Yilin ;

Meng, Minghui ;

Zheng, Zongji ;

Dong, Meng ;

Lin, Jun ;

Zhao, Qianwei ;

Zhang, Chuanhai ;

Yuan, Xiaoxue ;

Hu, Tao ;

Liu, Lieqin ;

Huang, Yuanyuan ;

Zhang, Lei ;

Wang, Dehua ;

Zhan, Jicheng ;

Lee, Hyuek Jong ;

Speakman, John R. ;

Jin, Wanzhu .

ENDOCRINOLOGY, 2015, 156 (07) :2461-2469

[42] Brown adipose tissue transplantation improves whole-body energy metabolism [J].

Liu, Xiaomeng ;

Zheng, Zongji ;

Zhu, Xiaoming ;

Meng, Minghui ;

Li, Lan ;

Shen, Yanyan ;

Chi, Qingsheng ;

Wang, Dehua ;

Zhang, Zhaoyun ;

Li, Chenzhong ;

Li, Yiming ;

Xue, Yaoming ;

Speakman, John R. ;

Jin, Wanzhu .

CELL RESEARCH, 2013, 23 (06) :851-854

[43] Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling [J].

Lockie, Sarah H. ;

Heppner, Kristy M. ;

Chaudhary, Nilika ;

Chabenne, Joseph R. ;

Morgan, Donald A. ;

Veyrat-Durebex, Christelle ;

Ananthakrishnan, Gayathri ;

Rohner-Jeanrenaud, Francoise ;

Drucker, Daniel J. ;

DiMarchi, Richard ;

Rahmouni, Kamal ;

Oldfield, Brian J. ;

Tschoep, Matthias H. ;

Perez-Tilve, Diego .

DIABETES, 2012, 61 (11) :2753-2762

[44] THE EFFECT OF INTERMITTENT COLD TREATMENT ON THE ADIPOSE-TISSUE OF THE CAT - APPARENT TRANSFORMATION FROM WHITE TO BROWN ADIPOSE-TISSUE [J].

LONCAR, D ;

BEDRICA, L ;

MAYER, J ;

CANNON, B ;

NEDERGAARD, J ;

AFZELIUS, BA ;

SVAJGER, A .

JOURNAL OF ULTRASTRUCTURE AND MOLECULAR STRUCTURE RESEARCH, 1986, 97 (1-3) :119-129

[45] Hypothalamic GLP-1: the control of BAT thermogenesis and browning of white fat [J].

Lopez, Miguel ;

Dieguez, Carlos ;

Nogueiras, Ruben .

ADIPOCYTE, 2015, 4 (02) :141-145

[46] Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans [J].

Matsushita, M. ;

Yoneshiro, T. ;

Aita, S. ;

Kameya, T. ;

Sugie, H. ;

Saito, M. .

INTERNATIONAL JOURNAL OF OBESITY, 2014, 38 (06) :812-817

[47] Bone morphogenic proteins signaling in adipogenesis and energy homeostasis [J].

Modica, Salvatore ;

Wolfrum, Christian .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2013, 1831 (05) :915-923

[48] Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells [J].

Mori, Masaki ;

Nakagami, Hironori ;

Rodriguez-Araujo, Gerardo ;

Nimura, Keisuke ;

Kaneda, Yasufumi .

PLOS BIOLOGY, 2012, 10 (04)

[49] Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation [J].

Mottillo, Emilio P. ;

Balasubramanian, Priya ;

Lee, Yun-Hee ;

Weng, Changren ;

Kershaw, Erin E. ;

Granneman, James G. .

JOURNAL OF LIPID RESEARCH, 2014, 55 (11) :2276-2286

[50] Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ [J].

Murano, I. ;

Barbatelli, G. ;

Giordano, A. ;

Cinti, S. .

JOURNAL OF ANATOMY, 2009, 214 (01) :171-178

← 1 2 3 4 5 6 7 8 9 →